INTACT Mass应用程序搭载于waters_connect信息学平台HUB(图2)中,可用于多种生物分子的质量数确认和纯度评估。也可以进行非靶向质量数分析以支持发现研究。此外,可以使用光学色谱图、TIC或质谱图进行纯度评估。 图2.waters_connect HUB包含与完整分...
BGI provides a service for intact mass analysis of complex mixtures of biologic isoforms, including moderate-to-high glycosylation or small molecule conjugation. High Dynamic Range (HDR) Intact Mass service combines data from both denaturing and native conditions. This service is based on size exclusi...
intact mass原理 Intact mass principle refers to the concept that the total mass of a system before and after a reaction or transformation remains the same, with no loss or gain of mass. This principle is based on the law of conservation of mass, which states that mass cannot be created ...
Intact Mass Analysis Charge Variant Analysis Protein Aggregate Analysis 滴度(亲和)分析 天然完整蛋白质量分析 Subunit Mass Analysis Deliver unequivocal intact mass assignments Among the analytical tools used for the characterization of proteins, high-resolution accurate-m...
Intact Mass Reproducibility | Biopharma Spotlight | Episode 3 of 7 Henry Shion, Principal Scientist at Waters, discusses implications from his tech brief, which illustrates how high-quality, consistent intact mass analysis is possible over an extended period of time on not just one, ...
INTACT Mass Workflow Demo | Automated Mass Confirmation and Purity Determination download video Learn More categories 关于沃特世 产品 应用领域 化药与中药 生物制药 生物医学研究 食品与环境 材料科学 临床诊断 网络讲座 教育 1:58
In this article, we focus on intact mass analysis-based multi-attribute methods (MAMs), a suitable alternative that can complement standard MAMs or be used when there is a need for rapid turnaround and monitoring of only a limited number of COAs. Multiple case studies are presented to ...
For intact mass detection, we combine algorithms for processing MS1 data from both isotopically resolved (FT) and charge-state resolved (ion trap) LC-MS data, which are then linked to their fragment ions for database searching using ProSight. Automated determination of human keratin and tubulin ...
Mass spectrometry, which measures the mass-to-charge ratio of molecules, has emerged as a potential solution with the development by Amgenin 2015of an LC-MS technique called the multi-attribute method (MAM). “There is a strong movement towards the implementation of MS in QC that is being ...
In this study, we report the application of intact mass spectrometry approaches to rapidly assess the outcome of X-ray footprinting experiments at the XFP beamline using lysozyme as a simple test protein. These top-down results are compared to Alexa488 dose-response data and bottom-up proteomics...