1.To investigate the effect of low-sodium-salt on expression of genes related toinsulin signaling pathwayamong the patients with obesity and high blood pressure,and to set up a local gene network model.研究低钠盐饮食对高血压与肥胖并发者血液中胰岛素信号通路相关基因表达的影响,初步找到表达发生变化的...
Summary The insulin signaling pathway, together with immediately adjacent or overlapping signaling pathways, is critical for sugar metabolism and cell proliferation. Some of the key proteins in this pathway—phosphoinositide 3 kinase (PI3K), phosphatase and tensin homolog (PTEN), and protein kinase B ...
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Insulin/IGF-1 Signaling Pathway Antibody Sampler Kit(1)结合特异性抗原:抗体与其他免疫球蛋白分子区别,就在于抗体能与相应抗原发生特异性结合,在体内导致生理或病理效应;在体外产生各种直接或间接的可见的抗原抗体结合反应。抗体是靠其分子上的特殊的结合部位与抗原结合的。
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Pathway analysis of the top 100 dmCpG-associated genes after adjustment for BMI showed enrichment of regulation of epidermal growth factor receptor (FDR 1.01 × 10−02) and regulation of protein kinase B signalling (FDR 1.89 × 10−02) and anatomical structure morphogenesis (FDR ...
(RPS6) genes. These genes play significant roles in the insulin signalling pathway among different castes of termites. The primers for each unigene are provided in Supplementary Table2. We evaluated the expression levels ofPdk1, which were somewhat lower in PKs and PQs, but there were no ...
Alternative pathway of insulin signaling in targeted disruption of the IRS-1 gene. Nature 372, 186–190 (1994). Article CAS PubMed Google Scholar Kubota, N. et al. Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus. J. Clin. Invest. 114, 917–927 (...
Dominici FP, Cifone D, Bartke A et al (1999) Loss of sensitivity to insulin at early events of the insulin signaling pathway in the liver of growth hormone-transgenic mice. J Endocrinol 161:383–392 Article PubMed CAS Google Scholar Dominici FP, Diaz GA, Bartke A et al (2000) Compens...
insulin signaling can potentially lead to deregulation of apoB synthesis and secretion. Upper panel illustrates the early biochemical events in the insulin signaling pathway and its modulators. Lower panel depicts some important factors that are postulated to be involved in the overproduction of VLDL-...