To understand the biological pathways that are involved inR. chinensis, we mapped the unigene sequences to the reference canonical pathways in the KEGG database. A total of 19,291 sequences were assigned to 343 KEGG pathways. They were related to metabolic pathways (26.23%), ribosomes (8.87%...
Gene ontology (GO, Biological Process) and KEGG pathway enrichment were determined from the largest network cluster. To investigate upstream regulators and effector networks, ingenuity pathway analysis (IPA) (Qiagen, UK) version 68752261 was used. Muscle epigenetic age estimation...
The KEGG enrichment analysis KEGG annotation files that contained 3525 worm genes annotated with at least one pathway were downloaded from the ftp server of KEGG (ftp://ftp.bioinformatics.jp/). The hypergeometric test was performed to detect enriched KEGG pathways (p < 0.05 and E-ratio ...
chinensis castes as a model organism for longevity to investigate the insulin signaling pathway and longevity genes. Through RNA-sequencing, we identified 35 IIS-pathway-related genes out of 343 to the KEGG pathway in ergatoid king and queen, PK, PQ, WM, and WF. Among these genes, Tsc2,...
signaling pathway. Hypermethylated genes in LC-CON group in the KEGG insulin signaling pathway.Hypermethylated genes in LC-CON group in the KEGG insulin signaling pathway.Zhang, QianSun, XiaofangXiao, XinhuaZheng, JiaLi, MingYu, MiaoPing, Fan...
The “KEGG insulin signaling pathway”, comprising 132 genes coding for various components of the insulin-dependent signaling cascade, was among the top ranking gene sets altered in mKO muscles (p=0.024) in both TA (Figure S7A) and SOL muscles (Figure S7B). Transcriptome analysis indicated ...
2.3. Pathway analysis Each of the 388 model reactions were assigned to KEGG pathway(s) (using EC number if available) or manually curated pathways (Supplemental Experimental Procedures). The 47 pathways are delineated in Supplemental File All KDs-fluxes, scores, and p-values.xls, pathways tab....
Amino acid metabolism was a shared KEGG pathway among the 2 omics (D) Full size image Fig. 6 LGG improves insulin resistance in late gestating sows by regulating the gut microbiota, branched-chain amino acid (BCAA), and kynurenine levels. BCAA levels in serum metabolites (A). Pearson’s ...
When mapped onto KEGG pathways, 11 highly enriched pathways were identified. On the basis of differences in expression of proteins belonging to the pathways in pseudoislets and monolayers, predictions of differential pathway activation were performed. Mechanisms enhancing insulin secretory capacity of the...
(Fig.6A, Supplementary TableS1). KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analyses using DAVID indicated that the genes involved in metabolic pathways, including those of protein, glucose and fat were also altered (Fig.6B). The differences in the ribosome pathway presumably reflected...