Insulin resistance precedes 尾-cell dysfunction and plays a key role in the development of type 2 diabetes. After carbohydrate ingestion, insulin stimulates the storage of glucose as glycogen in muscle and liver,
“Insulin resistance leads to diabetes when the pancreas can no longer keep up with the increased demand for insulin,” Dr. Alatassi says. “Eventually, the pancreas becomes overworked and its ability to produce insulin declines, leading to elevated blood sugar levels and the onset oftype 2 dia...
While traditionally being considered as a problem of highly developed societies, obesity and diabetes are on the rise in low‐ and middle‐income countries, reaching pandemic proportions. Therefore, there is a clear need to better understand the molecular mechanisms of insulin resistance and to ...
Nearly unlimited supplies of energy-dense foods and technologies that encourage sedentary behaviour have introduced a new threat to the survival of our species: obesity and its co-morbidities. Foremost among the co-morbidities is type 2 diabetes, which is projected to afflict 300 million people worl...
In conclusion, insulin treatment of type 2 diabetes patients leads to decrease in insulin resistance due to reduction in glucose toxicity and plasma atherogenicity despite weight gain. Introduction Now from 10 to 30% patients with type 2 diabetes (T2DM) require insulin treatment for optimal ...
ILs are probably involved in the pathology and physiology of insulin resistance and type 2 diabetes mellitus via their effects on both insulin-signaling pathways and β-cell or α-cell function Two IL systems seem to have a central role in this pathological context: IL-6 and the balance betwee...
Insulin resistance (IR) is a major metabolic risk factor even before the onset of hyperglycemia. Recently, berberine (BBR) is found to improve hyperglycemia and IR. In this study, we investigated whether BBR could improve IR independent of hyperglycemia.
Thus, a similar degree of insulin deficit seems to exist in both types of diabetes, which leads me to conclude that insulin resistance in T2DM is not the main factor inducing hyperglycemia. β-Cell function during the development of type 2 diabetes The earliest modifi...
It is known that an excess of thyroid hormone leads to increased oxidant production and mitochondrial oxidative damage. It can be hypothesized that these species represent the link between hyperthyroidism and development of insulin resistance and diabetes, even though direct evidence of this relationship...
Eriksson JW, Smith U, Waagstein F, Wysocki M, Jansson PA. Glucose turnover and adipose tissue lipolysis are insulin-resistant in healthy relatives of type 2 diabetes patients: is cellular insulin resistance a secondary phenomenon? Diabetes 1999;48:1572–1578. ...