Type 2 diabetesInsulin target tissuesHuman pluripotent stem cellsInduced pluripotent stem cellsGenetic factorsDisease modelingIn this review, we discuss the insulin resistance (IR) and its development in the insulin target tissues that leads to diabetes. Also, we highlight the use of induced pluripoten...
Association of Serum Magnesium Deficiency with Insulin Resistance in Type 2 Diabetes Mellitus. BACKGROUND: Insulin resistance (IR) is the key pathophysiological defect that leads to the development of type 2 diabetes mellitus. The purpose of this stu... H Chutia,KG Lynrah - 《Journal of Laborat...
Insulin resistance instills when target tissues lose their responsiveness to the hormone and has long been considered to be central to the pathophysiology of metabolic disorders such as type 2 diabetes (T2D), obesity, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD)3. Insulin ...
When we have insulin resistance, insulin doesn’t regulate our blood glucose levels as well, and it often leads to type 2 diabetes. “Chronic, low grade tissue inflammation is an important cause of obesity-related insulin resistance,” the study states. As I have reportedherepreviously, Dr. O...
In type 2 diabetes, there is a defect in the regulation of functional β-cell mass to overcome high-fat (HF) diet–induced insulin resistance. Many signals and pathways have been implicated in β-cell function, proliferation and apoptosi... I.,Takamoto,Y.,... - 《Diabetes Obesity & Metab...
It should be pointed out that insulin levels in our blood often spike, which can also have serious consequences. If the insulin level in our blood constantly rises, it will gradually make the body's cells less sensitive to insulin, c...
Hyperinsulinemia and insulin resistance contribute to obesity, type 2 diabetes (T2D) and associated metabolic disorders [1,2]. Pancreatic β-cells secrete insulin primarily in response to increasing blood glucose levels, through the production of metabolic coupling factors (MCF) that promote insulin gra...
Thus, a similar degree of insulin deficit seems to exist in both types of diabetes, which leads me to conclude that insulin resistance in T2DM is not the main factor inducing hyperglycemia. β-Cell function during the development of type 2 diabetes The earliest modifi...
Here’s Dr. Taylor’s Twin Cycle Hypothesis of Etiology of Type 2 Diabetes: “The accumulation of fat in liver and secondarily in the pancreas will lead to self-reinforcing cycles that interact to bring about type 2 diabetes. Fatty liver leads to impaired fasting glucose metabolism and increase...