In conclusion, insulin treatment of type 2 diabetes patients leads to decrease in insulin resistance due to reduction in glucose toxicity and plasma atherogenicity despite weight gain.doi:10.1016/j.diabres.2005.03.007Alexander Yu. MayorovIrina V. Naumenkova...
Signs and symptoms of insulin resistance can include a large waist, other signs of metabolic syndrome, or dark skin patches.
While traditionally being considered as a problem of highly developed societies, obesity and diabetes are on the rise in low‐ and middle‐income countries, reaching pandemic proportions. Therefore, there is a clear need to better understand the molecular mechanisms of insulin resistance and to ...
diabetes is also a problem with excess fat, especially too much fat inside skeletal muscle, which leads to the insulin resistance. If the level of fat in
Thus, a similar degree of insulin deficit seems to exist in both types of diabetes, which leads me to conclude that insulin resistance in T2DM is not the main factor inducing hyperglycemia. β-Cell function during the development of type 2 diabetes The earliest modifi...
However, during insulin resistance (IR), when insulin signalling is blunted and accompanied by hyperinsulinaemia, the promotion of hepatic DNL continues unabated and hepatic steatosis increases. Here, we show that WD40 repeat-containing protein 6 (WDR6) promotes hepatic DNL during IR. ...
Eat Weight Disord (2014) 19:275–283 DOI 10.1007/s40519-014-0139-y REVIEW The therapy of insulin resistance in other diseases besides type 2 diabetes Laura Pala • Valeria Barbaro • Ilaria Dicembrini • Carlo Maria Rotella Received: 5 April 2014 / Accepted: 30 June 2014 / Published ...
It is known that an excess of thyroid hormone leads to increased oxidant production and mitochondrial oxidative damage. It can be hypothesized that these species represent the link between hyperthyroidism and development of insulin resistance and diabetes, even though direct evidence of this relationship...
It was thought that this leads to hyperglycaemia, which has a further effect in reducing insulin secretion via ‘glucose toxicity’ [1]. We began our research into the role of innate immunity in type 2 diabetes at this time, with the aim of exploring whether type 2 diabetes, dyslipidaemia ...
Diabetes, either of two disorders of the endocrine system. For information about the disorder caused by the body’s inability to produce or respond to insulin and characterized by abnormal glucose levels in the blood, see diabetes mellitus. For informati