Insulin resistance and type 2 diabetes are complex conditions which carry with them major health risk of increased morbidity and mortality. Insulin resistance is a genetic predisposition in which the normal actions of insulin are impaired. Only in the face of environmental stress of such factors as...
Type 2 diabetes mellitus, the most frequent subtype of diabetes, is a disease characterized by high levels of blood glucose (hyperglycaemia). It arises from a resistance to and relative deficiency of the pancreatic β-cell hormone insulin. ...
Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes remain largely unclear. Insulin resistance, the common underlying abnormality, results from imbalance between energy intake and expenditure favouring nutrient-storage pathways, which evolved to maximize energy utilization...
TNF伪 induces insulin resistance in type 2 diabetes, but its mechanism of action is not fully understood. We have found a selective increase in the acidic glycosphingolipid ganglioside GM3 in 3T3-L1 adipocytes treated with TNF伪, suggesting a specific function for GM3. We were able to ...
Diabetes, either of two disorders of the endocrine system. For information about the disorder caused by the body’s inability to produce or respond to insulin and characterized by abnormal glucose levels in the blood, see diabetes mellitus. For informati
Type 2 diabetes is a condition in which the cells cannot use blood sugar efficiently to meet the body’s needs. Learn about symptoms, causes, vs. type 1 diabetes, diet, exercise, treatment, insulin, medications, life expectancy, and other lifestyle chang
In type 2 diabetics, the body either doesn't produce enough insulin or is unable to use the insulin properly. Insulin is vital to the body as it allows the body to use glucose for energy. The body works to break down all of the sugars found in food into glucose. It is the insulin'...
Type 2 diabetes is a major metabolic disease characterized by hyperglycemia and insulin resistance, affecting over 390 million people around the globe (1). The traditional hypothesis for its pathogenesis is that obesity leads to insulin resistance and hyperglycemia, resulting in compensatory ...
Insulin resistance is a core feature of type 2 diabetes mellitus (T2DM) and contributes not only to the hyperglycaemia that defines diabetes mellitus but also to the hyperlipidaemia, inflammation, oxidative stress and atherosclerosis that accompany it ...
Insulin resistance is a core feature of type 2 diabetes mellitus (T2DM) and contributes not only to the hyperglycaemia that defines diabetes mellitus but also to the hyperlipidaemia, inflammation, oxidative stress and atherosclerosis that accompany it T2DM substantially increases risk of not only cerebro...