The role of mitochondria in insulin resistance and type 2 diabetes mellitus . Nat Rev Endocrinol 8 : 92 – 103 .Szendroedi J, Phielix E, Roden M (2011) The role of mitochondria in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol 8:92–103...
Type 2 diabetes mellitus, the most frequent subtype of diabetes, is a disease characterized by high levels of blood glucose (hyperglycaemia). It arises from a resistance to and relative deficiency of the pancreatic β-cell hormone insulin. ...
TNF伪 induces insulin resistance in type 2 diabetes, but its mechanism of action is not fully understood. We have found a selective increase in the acidic glycosphingolipid ganglioside GM3 in 3T3-L1 adipocytes treated with TNF伪, suggesting a specific function for GM3. We were able to ...
Diabetes, either of two disorders of the endocrine system. For information about the disorder caused by the body’s inability to produce or respond to insulin and characterized by abnormal glucose levels in the blood, see diabetes mellitus. For informati
Type 2 diabetes is a condition in which the cells cannot use blood sugar efficiently to meet the body’s needs. Learn about symptoms, causes, vs. type 1 diabetes, diet, exercise, treatment, insulin, medications, life expectancy, and other lifestyle chang
In type 2 diabetics, the body either doesn't produce enough insulin or is unable to use the insulin properly. Insulin is vital to the body as it allows the body to use glucose for energy. The body works to break down all of the sugars found in food into glucose. It is the insulin'...
Type 2 diabetes is a major metabolic disease characterized by hyperglycemia and insulin resistance, affecting over 390 million people around the globe (1). The traditional hypothesis for its pathogenesis is that obesity leads to insulin resistance and hyperglycemia, resulting in compensatory ...
Insulin resistance is a core feature of type 2 diabetes mellitus (T2DM) and contributes not only to the hyperglycaemia that defines diabetes mellitus but also to the hyperlipidaemia, inflammation, oxidative stress and atherosclerosis that accompany it ...
This contributes to the pathogenesis of several diseases, including obesity-related insulin resistance (IR) and type 2 diabetes (T2D) [1]. This is typically manifest by an excess of nutrients which cause adipose tissue (AT) and pancreatic β-cells to secrete cytokines, thereby making them the ...
Insulin resistance is a core feature of type 2 diabetes mellitus (T2DM) and contributes not only to the hyperglycaemia that defines diabetes mellitus but also to the hyperlipidaemia, inflammation, oxidative stress and atherosclerosis that accompany it T2DM substantially increases risk of not only cerebro...