Lewis MR, Tracy RP. The role of the immune system in the insulin resistance syndrome. Curr Diab Rep. 2002; 2 :96–99.Lewis MR, Tracy RP (2002) The role of the immune system in the insulin resistance syndrome. Curr Diab Rep 2: 96-99....
Genetic variations leading to the altered production or function of circulating innate immune proteins, cellular pattern recognition receptors and inflammatory cytokines are linked to obesity, insulin resistance and type 2 diabetes. Components of the innate immune system in the muscle, bone, liver and ...
In this review, we provide new insights into factors, such as, the renin angiotensin aldosterone system, sympathetic activation and incretin modulators (e.g., DPP-4) and immune responses that mediate this inflammatory state in obesity and other conditions characterized by insulin resistance. (C) ...
They developed a cell-based system to mimic age-related inflammation, with the aim of mimicking the effects of inflammation on insulin resistance during aging (Komleva et al., 2021), which is experiments combined with aging mouse models. It was conclusively proven that aging associated inflammation...
Insulin resistance may contribute to the pathogenesis of hypertension and progressive chronic kidney disease (CKD), however, few clinical studies have expl... H Kobayashi,G Tokudome,Y Hara,... - 《Clinical Nephrology》 被引量: 60发表: 2009年 The Role of Synaptic Proteins in the Pathogenesis of...
The intestinal immune system is emerging as an important contributor to obesity-related insulin resistance, but the role of intestinal B cells in this context is unclear. Here, we show that high fat diet (HFD) feeding alters intestinal IgA+ immune cells
In this Review, the authors describe the factors that influence the development of hepatic steatosis and discuss the evidence base that links steatosis to insulin resistance. They explore how steatosis alters the secretion of hepatokines from the liver,
Such mechanisms explain the transition from excess adiposity to insulin resistance, key to the further development of type 2 diabetes. 展开 关键词: Insulin resistance FFA Metabolic syndrome Obesity Diabetes Cytokine DOI: 10.1016/j.vph.2012.05.003 被引量: 286 ...
1. Introduction 2. Definition of obesity 3. Prevalence and incidence of obesity 4. Risk factors of obesity 5. Cellular dysfunctions associated with obesity-induced insulin resistance 6. Conclusion Funding Declaration of Competing Interest ReferencesShow full outline Cited by (406) Figures (5)Biomedic...
Brain insulin resistance can be defined as the failure of brain cells to respond to insulin as they normally would, resulting in impairments in synaptic, metabolic and immune response functions T2DM is associated with brain insulin resistance, and studies suggest that brain insulin resistance is a ...