Resistance to insulin-stimulated glucose uptake is present in the majority of patients with impaired glucose tolerance (IGT) or non-insulin-dependent diabetes mellitus (NIDDM) and in 25% of nonobese individuals with normal oral glucose tolerance. In these conditions, deterioration of glucose toleranc...
Resistance to insulin-stimulated glucose uptake is present in the majority of patients with impaired glucose tolerance (IGT) or non-insulin-dependent diabetes mellitus (NIDDM) and in 25% of nonobese individuals with normal oral glucose tolerance. In these conditions, deterioration of glucose tolerance...
Human adiposity has long been associated with insulin resistance and increased cardiovascular risk, and abdominal adiposity is considered particularly adverse. Intra-abdominal fat is associated with insulin resistance, possibly mediated by greater lipolytic activity, lower adiponectin levels, resistance to le...
Insulin resistance in human disease. Amsterdam: Experta Medica; 1993. pp. 7–12.Huh KB, (1993), The role of insulin resistance in Korean patients with metabolic and cardiovascular diseases, in Insulin Resistance in H u m a n Disease, eds H u h K B , Shinn SH, Kaneko T, Elsevier ...
several distinct inflammasome-targeting therapies. Therefore, understanding how different inflammasomes contribute to disease pathology may have significant implications for developing novel therapeutic strategies. In this article, we provide a summary of the biological and pathological roles of inflammasomes in...
For this issue, we invite the submission of articles that may contribute to a better understanding of the effects of all types of vitamins on the human body, both in health as well as in disease. These submissions can be based on studies of physiological function and regulation mechanism of ...
targets for the development of novel therapeutic approaches for metabolic syndrome. The past few decades have seen intense research efforts to determine how these kinases are regulated in a cell-specific manner and to define their contribution to the development of obesity and insulin resistance. Sever...
内容提示: cellsArticleRole of Chitinase 3-Like 1 Protein in the Pathogenesis of HepaticInsulin Resistance in Nonalcoholic Fatty Liver DiseaseSonghua Zhang1 , Aryanna Sousa 1, Mengqui Lin1 , Ayako Iwano 1 , Rishubh Jain 1 , Bing Ma 2 , Chang Min Lee 2 ,Jin Wook Park2 , Suchitra Kam...
The impact of microbial pathogens and their strategic treatment on microbial dysbiosis and their outcome in the human host Full size image The influence of microbiota on our health and disease status is exerted in many directions. They can induce/modify metabolic-, auto-immunogenic, and neurodegenera...
Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ (PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances in protein structure determination and drug development have allowed for generati