diabetesinsulin actioninsulin receptor substratesinsulin receptorsinsulin resistanceIRS1IRS2pancreatic β cellsphosphatasesPI3KInsulin and IGF (insulin-like growth factor) signaling integrates the storage and release of nutrients with animal growth during development and throughout adult life. It is essential ...
D Alvares,S Hoffman,K Adeli - 《Diabetes》 被引量: 0发表: 2022年 Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism Acute exercise can reverse muscle insulin resistance, but the mechanism(s) of action are...
Research Progresses of the Mechanism of Insulin Resistance in Type II Diabetes II型糖尿病胰岛素抵抗机制的研究进展 相关领域 胰岛素抵抗 胰岛素受体 内科学 2型糖尿病 内分泌学 IRS1 蛋白激酶B 蛋白激酶A PI3K/AKT/mTOR通路 胰岛素受体底物 信号转导 胰岛素 MAPK/ERK通路 糖尿病 脂联素 医学 激酶 化学 生物...
Sulfonylureas reduce plasma glucose concentrations in most patients with non-insulin-dependent diabetes mellitus (NIDDM). The mechanism of this action is controversial. In this article we examine the issue of the peripheral effect of these drugs, i.e., the effect on insulin receptors and insulin ...
However, the association between ceramides and insulin resistance has not been observed in all studies and their mechanism of action is still ill-defined (Chaurasia et al., 2020; Petersen and Shulman, 2018). As is the case for DAGs, structural variations among ceramide species (acyl chain ...
(1994) Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor. EMBO J 13: pp. 835-842 Krook, A., Moller, D.E., Dib, K. (1996) Two naturally occurring mutant insulin receptors phosphorylate insulin receptor substrate...
A series of synthetic peptides corresponding to the amino-terminal sequence of human growth hormone (hGH) has been studied for insulin-potentiating effects... F M,Ng,Bornstein,... - 《Diabetes》 被引量: 31发表: 1980年 The role of calcium in insulin action. IV. Mechanism of insulin resista...
et al. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J. Clin. Invest. 92, 1824–1830 (1993). Article PubMed PubMed Central CAS Google Scholar Banks, W. A., Jaspan, J. B., Huang...
Diabetes 53, 25–31 (2004). Article CAS Google Scholar Stratford, S., Hoehn, K. L., Liu, F. & Summers, S. A. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J. Biol. Chem. 279, 36608–36615 (2004...
activates IR and mimics insulin’s action on glycemic control. To elucidate the mechanism of IR activation by S597, we determine cryo-EM structures of the mouse IR/S597 complex. Unlike the compact T-shaped active IR resulting from the binding of four insulins to two distinct sites, two S...