Diabetologia (1982)23:381~85 Diabetologia 9 Springer-Verlag 1982 Controversial Topics The Mechanism of Insulin Action The Interaction of Insulin with its Receptor: Cross-linking via Insulin Association as the S
Solanum nigrum Linn is a medicinal herb widely used in traditional Chinese medicine to treat ailments such as fever, inflammation and cancer. Although quit
When there is inflammation, the intestinal microenvironment becomes extremely complicated, and many different types of cells release cytokines, such as interleukin (IL) and TNF, which can trigger inflammatory response via the action of complicated cellular subnets and accelerate, postpone, or even ...
Developing an agent that enables long-term storage of insulin at ambient temperature while preserving its structural integrity and functional activity would enhance storage convenience and advance automated insulin pumps. To analyze the impact of the polymers on insulin fibrillation, we used a thioflavin...
a: Venn diagram of intersecting targets of TMJOA and alpinumisoflavone; b: potential PPI protein interaction network for treating TMJOA with alpinumisoflavone; c: the PPI network diagram drawn by Cytoscape (the node area represents the target degree value, and the more important the target has the...
Suanzaoren Decoction (SZRD), a well-known formula from traditional Chinese medicine, has been shown to have reasonable cognitive effects while relaxing and alleviating insomnia. Several studies have demonstrated significant therapeutic effects of SZRD on
5 Secondary structure diagram and sequence alignment of human GPAT1 with mammalian and bacterial GPAT orthologs. The protein sequences were extracted from UniProt accession numbers Q9HCL2 from Homo sapiens (GPAT1_HUMAN); Q61586 from Mus musculus (GPAT1_MOUSE); P97564 from Rattus norvegicus (GPA...
Mechanisms of action of antiseizure drugs and the ketogenic diet. Cold Spring Harb Perspect Med. 2016;6:28. 39. Mujica-Parodi LR, Amgalan A, Sultan SF, Antal B, Sun X, Skiena S, et al. Diet modulates brain network stability, a biomarker for brain aging, in young adults. Proc Natl...
limited amyloid misfolding has been postulated92. The law of mass action shifts the monomer equilibrium toward the unfolded state, thus allowing amyloid formation even under physiological conditions where only small amounts of unfolded precursor are present upon the breakdown of the supersaturation. The...
In conclusion, this study combines network pharmacology, molecular docking, molecular dynamic simulation, and animal experimental verification for the first time to study the effectiveness and mechanism of action of OA in the treatment of obesity. The findings reveal the potential of OA in the treatme...