Insulin is a protein hormone that controls the metabolism of sugar, fat and protein via signal transduction in cells, influencing growth and developmental processes such as reproduction and ageing. From nematodes to fruit flies, rodents and other animals, glucose signalling mechanisms are highly conserv...
A Chiba research team near Tokyo has discovered a protein sensor molecule that it says is closely related to the secretion of insulin from the beta cells of the pancreas. This may be important in its implications for the development of new treatment for diabetes....
[ 32 P]GDP release from the liver membranes was proportional to the protein concentration and increased as a function of time. At 5 mM, Ca 2+ , Mg 2+ , Mn 2+ , and Zn 2+ maximally inhibited GDP release by 80–90%, whereas, 5 mM Cu 2+ maximally stimulated the reaction by 100%...
作者: T Yoshizaki,H Maegawa,K Egawa,S Ugi,Y Nishio,T Imamura,T Kobayashi,S Tamura,JM Olefsky,A Kashiwagi 展开 摘要: During differentiation, expression of protein phosphatase-2Calpha (PP2Calpha) is increased in 3T3-L1 adipocytes. To elucidate the role of PP2Calpha in insulin signaling, ...
Insulin (INS) 抗体应用备注Immunohistochemistry on Frozen Sections. ELISA: This antibody is suitable for use as a Detection antibody with BM507 as the Captureantibody. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. ...
This protein carries a polyhistidine tag at the C-terminus. The mature form of Insulin R a disulfide-linked heterotetramer composed of 2 alpha and 2 beta chains. Each α and β chain (partial fragment) has a calculated MW of 83.6 kDa and 22.8 kDa. The protein migrates as 120-130 kDa...
Identification of a 190-kDa Protein as a Novel Substrate for the Insulin Receptor Kinase Functionally Similar to Insulin Receptor Substrate-1 来自 掌桥科研 喜欢 0 阅读量: 25 作者: Tamemoto,H.摘要: Recently, we generated mice with a targeted disruption of the insulin receptor substrate-1 (IRS-...
Remarkably, β-amyloid (Aβ1-40/42) peptide levels were as follows: increased in the short term by insulin in normal mice, increased basally in insulin-resistant mice and monkeys, and accompanied by diminished amyloid precursor protein in monkeys. Phosphorylated tau levels were increased in ob/...
gene located onchromosome 19, which is expressed in nearly all tissues of the body except thebrain, which is able to utilise glucose without the action of insulin. The receptor is synthesised as a single protein. The subunits are separated byproteolysisand then re-connected withdisulphide bridges...
To analyse the effects of insulin valency on IR activation, we treated cultured adipocytes with insulin NanoRods of various valencies for 10 min, at a constant total insulin concentration, and analysed the phosphorylation levels of IR as well as the downstream protein AKT by western blot (Fig...