Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity fro... 1984. Insulin receptor is an insulin-dependent tyrosine protein kinase: Copurification of insulin-binding activity and protein kinase activity to ...
As insulin-like growth factor-1 (IGF-1) is present in the alpha granules of platelets and its receptor is expressed on the platelet surface, it may contrib... I Hers - 《Blood》 被引量: 121发表: 2007年 Characterisation of insulin-like growth factor-binding protein-3 binding to a novel...
Insulin is a more important predictor for leptin than insulin-like growth factor-binding protein 1 and growth hormoneWhether the decrease of insulin action is a biological consequence of age or a result of lifestyle changes in elderly people is uncertain. Therefore, we rigorously controlled ...
It is concluded that either the protein-tyrosine kinase activity of the insulin receptor or its phosphorylation state is essential for ligand-mediated receptor down-regulation. 展开 DOI: 10.1016/S0021-9258(18)60889-0 被引量: 861 年份: 1987 ...
The insulin/IGF binding protein-1 (IGFBP-1) axis is important in coordinating insulin- and IGF-mediated regulation of glucose metabolism and glycemia. Dysregulation of the axis may play a role in the pathophysiology of disorders of insulin deficiency and resistance. We have investigated this hypothe...
We examined the effect of insulin on the expression of the activity-regulated cytoskeleton-associated gene (ARC), an effector immediate early gene with a proposed role in memory formation. In human SH-SY5Y neuroblastoma cells, application of insulin leads to dramatic increase in ARC mRNA and prot...
The purpose of this study was to characterize insulin-like growth factor-1 receptor (IGF1R) protein expression, mRNA expression, and gene copy number in surgically resected non-small-cell lung cancers (NSCLC) in relation to epidermal growth factor receptor (EGFR) protein expression, patient charact...
α-Crystallin is a major structural protein of the lens; it accounts for nearly 40% of the total protein in the lens and is required for maintenance of lens transparency.1The lens grows throughout age, though at a very slow rate. The proteins in the lens have negligible turnover and ther...
Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in radiosensitivity of esophageal squamous cell carcinoma (ESCC). However, the underlying mechanism is not completely understood. Here, we observed that IGFBP-3 had favorable
S2b). The predicted increase in insulin receptor signaling in OPA1-LKO mice is consistent with their augmented insulin sensitivity evaluated by GTT (Fig. 1d). Fig. 4: OPA1 LKO alters the liver proteome by the ISR. a The protein heatmaps for >2-fold changes in PSM scores in the lysate...