Innate lymphoid cells (ILCs) are immune cells that belong to the lymphoid lineage but do not express antigen-specific receptors. These cells have important functions in innate immune responses to infectious microorganisms and in the regulation of homeostasis and inflammation. ...
Innate lymphoid cells (ILCs) are involved in many inflammatory disorders but appear to be redundant for protective immunity in humans under modern conditions of hygiene and medicine when T cell and B cell functions are preserved. The plasticity of ILCs and their ability to adopt a pro-inflammatory...
ILCs include lineage marker negative (lin-) ILCs,natural killer (NK) cells, and lymphoid tissue-inducer (LTi) cells. Three distinct groups of ILCs have been classified based upon their immune response of Type 1, 2, and 3. Grou...
其次,通过单细胞聚类和t-SNE分析确定了主要的ILCS分群(图3D)。ILCs主要亚群的鉴定是通过特征Marker的转录本 或膜蛋白Abseq(图3E)并进一步将ILCs注释为4大胞亚群(ILC1sILC2、ILC3s和NK-ike)及12个分亚群(图3F)。 相比于肿瘤组织,非肿瘤NK-like细胞富集ILC3s转录本,其特征与之前报告过的NK-ike progenitor相似(...
Figure 3. Exogenous IL-33 enhances group 2 innate lymphoid cell (ILC2) responses and promotes cutaneous wound healing. (a, b) Frequencies and total cell numbers of IL-5 and IL-13-expressing innate lymphoid cells (ILCs) in day 5 wounds of control (PBS) and rmIL-33 treated mice (n = ...
Innate Lymphoid Cells Innate lymphoid cells(ILCs), a heterogeneous group of cells of the innateimmune system, have lymphoid morphology but lack the capacity for rearrangement of the antigen receptors, a cardinal feature of the cells of theadaptive immune system.18Conventional natural killer (NK) cel...
Allergic contact dermatitis is an inflammatory skin disease that is mediated by our immune system. In this chapter we summarize current methods for the diagnosis of contact dermatitis and...S...
固有淋巴样细胞(innate lymphoid cells,ILCs)——来源于骨髓共同淋巴样前体,由转录因子ID2+固有淋巴样前体发育分化而成。包括ILC1/2/3三个亚群, 以及NK细胞。不表达特异性/泛特异性抗原受体,故其活化不依赖于对抗原的识别。此类淋巴细胞表达一系列与其活化或抑制相关的受体,可被感染部位组织细胞产生的某些细胞因子或...
既往研究确定了2型固有淋巴细胞(innate lymphoid cells, ILCs)在小鼠肝纤维化发展中的作用,但ILCs在人类肝细胞癌(HCC)中的生物学功能仍不清楚。关于肝癌肿瘤微环境中调控ILCs的细胞因子的动态变化知之甚少。本项研究发现调控ILCs的细胞因子在非肿瘤和肿瘤组织中差异表达,并与TCGA-HCC队列中的预后相关。ILCs的轨迹分析...
3. Chromosomal marker analysis of single antibody-forming cells in reconstituted, irradiated, or thymectomized mice. J. Exp. Med. 128, 839–853 (1968). Article CAS PubMed PubMed Central Google Scholar Kiessling, R., Klein, E. & Wigzell, H. “Natural” killer cells in the mouse. I....