Cancer immunotherapyInnate lymphoid cells (ILCs)Plasticity TumorigenesisTumor microenvironment (TME)Innate lymphoid cells (ILCs), a critical component of the immune system, have recently been nominated as emerging players associated with tumor progression and inhibition. ILCs are classified into five groups...
The innate lymphoid cell (ILC) family is composed of natural killer (NK) cells, ILC1, ILC2 and ILC3, which participate in immune responses to virus, bacteria, parasites and transformed cells. ILC1, ILC2 and ILC3 subsets are mostly tissue-resident, and ar
先天性淋巴细胞（Innate Lymphoid Cells）先天免疫系统由⼀系列进化上古⽼的造⾎细胞组成，包括树突状细胞、单核细胞、巨噬细胞和粒细胞。这些细胞群相互协作，与适应性免疫系统和⾮造⾎细胞，以促进免疫，炎症和组织修复。先天性淋巴细胞是最近发现的先天性免疫系统的组成部分，在过去五年中⼀直是研究的热点。
固有淋巴样细胞(innate lymphoid cells,ILCs)——来源于骨髓共同淋巴样前体,由转录因子ID2+固有淋巴样前体发育分化而成。包括ILC1/2/3三个亚群, 以及NK细胞。不表达特异性/泛特异性抗原受体,故其活化不依赖于对抗原的识别。此类淋巴细胞表达一系列与其活化或抑制相关的受体,可被感染部位组织细胞产生的某些细胞因子或...
The unique role of innate lymphoid cells in cancer and the hepatic microenvironment Article Open access 12 August 2022 Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells Article 24 November 2020 Inflammatory processes in the liver: divergent roles in homeosta...
The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma 前言 肝癌的一个诱发因素是肝脏慢性炎症,它主要是由于感染HBV/HCV病毒或者酒精性和非酒精性脂肪肝引起的。细胞因 子在肝脏炎症和肝癌发展过程中的调节免疫过程起着重要作用。ILCs参与形成细胞因子环境并受细胞因子调节,调...
Innate Lymphoid Cells Innate lymphoid cells (ILCs) are recently identified cells residing mainly at mucosal and barrier surfaces that are able to respond rapidly to a wide range of soluble mediators released during cellular stress and danger. They mediate signals to regulate inflammation, immunity, ti...
近日,西湖大学徐和平团队在Immunity 在线发表题为“Retinoid X receptor gamma dictates the activation threshold of group 2 innate lymphoid cells and limits type 2 inflammation in the small intestine”的研究论文,该研究发现类视黄醇X受体γ (Rxrg)在小肠ILC2s中高表达 ...
These processes are often incompatible with each other and must therefore be prioritized in view of the most crucial contemporary needs of the host. Recent work has shown that tissue-resident innate lymphoid cells (ILCs) constitute a central sensory module allowing adaptation of intestinal organ ...
Innate lymphoid cells (ILCs) are a new, intriguing cell populations involved with tissue development, remodeling, and inflammation. However, classifying these cells has been difficult due to a variety of naming conventions. Learn more about these ce