The innate immune system is composed of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, monocytes, macrophages and granulocytes. These cell populations collaborate with each other, with the adaptive immune
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Innate lymphoid cells (ILCs) are particularly resident in the mucosal barrier and participate in several pathophysiological processes, such as maintaining or disrupting barrier integrity, preventing various pathogenic invasions. In the pulmonary mucosae, ILCs sometimes aggravate inflammation and mucus hyper...
innate immunity viral immunity poxvirus intravital microscopy innate lymphoid cell NK cell Introduction Innate lymphoid cells (ILCs) are a heterogeneous group of tissue-resident lymphocytes that bridge innate and adaptive immunity by responding rapidly to invading pathogens without the antigen-specific recepto...
124. Maazi H, Banie H, Aleman Muench GR et al (2018) Activated plasmacytoid dendritic cells regulate type 2 innate lymphoid cell–mediated airway hyperreactivity. J Allergy Clin Immunol 141(3):893-905.e6. https://doi.org/10.1016/j.jaci.2017.04.043 ...
Therefore, we reason that the immune regulation that tightly governs stem cell niche biology might also be relevant to the niche that fosters metastatic progression. Here, we comprehensively explore the dynamics of immune cells in the earliest metastatic microenvironment of the lung and interrogate the...
DOI: 10.1016/j.cell.2023.12.016 ②Cell:Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death 通过诱导颗粒酶B介导的肿瘤细胞死亡对人类2型先天性淋巴细胞的治疗应用 DOI: 10.1016/j.cell.2023.12.015 ...
As the first line of defense, innate immunity plays an important role in protecting the host against pathogens. Innate lymphoid cells (ILCs) are emerging as important effector cells in the innate immune system and the cell type that regulate immune and tissue homeostases. Group 2 ILCs (ILC2s)...
We proposed that this type of innate-like activity exerted by MP cells may significantly contribute to the innate immune resistance mediated by natural killer (NK) cells, innate lymphoid cells (ILCs), and virtual memory CD8+ T lymphocytes3,4,5. Despite the phenotypic similarities between MP and...
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