Two new antifungal antibiotics, neopeptins A and B have been discovered in our screening studies for inhibitors of microbial cell wall biosynthesis at the enzyme level. The antibiotics were isolated from a fermentation broth of Streptomyces sp. K-710. They have the molecular formulae corresponding...
β-Lactam antibiotics have long been a treatment of choice for bacterial infections since they bind irreversibly to Penicillin-Binding Proteins (PBPs), enzymes that are vital for cell wall biosynthesis. Many pathogens express drug-insensitive PBPs rendering β-lactams ineffective, revealing a need for...
Cellulose Biosynthesis Inhibitors as Tools for Research of Cell Wall Structural Plasticity 作者: Alvarez, Jesus Miguel; Encina, Antonio; Garcia-Angulo, Penelope 页数: 84ISBN: 9781614709466豆瓣评分 目前无人评价 评价: 写笔记 写书评 加入购书单 分享到 ...
A series of arabinose glycosyl sulfamides with varying alkyl chain types and lengths were synthesised as mimics of decaprenolphosphoarabinose (DPA), and as potential inhibitors of mycobacterial cell wall biosynthesis. Unprecedented conversion of the desired furanose to the thermodynamically more stable ...
Creative Biolabs provides customers with antibacterial drug development services that inhibit bacterial protein synthesis.
MP Lambert,FC Neuhaus - 《Journal of Bacteriology》 被引量: 401发表: 1972年 Exploitation of structural and regulatory diversity in glutamate racemases Glutamate racemase is an enzyme essential to the bacterial cell wall biosynthesis pathway, and has therefore been considered as a target for antibacte...
The invention relates to compounds which inhibit the Mycobacterial enoyl-ACP reductase required for cell wall biosynthesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of use of these compounds for treating a bacterial infection in a patient.收藏...
Surprisingly, the _ssrA strain is more sensitive than wild type to inhibitors of cell wall synthesis: fosfomycin and ampicillin. No growth difference was observed on drugs with other target sites: ofloxacin, norfloxacin, rifampicin and trimethoprim. Sensitization to antibiotics having target sites other...
Based on similarity of symptoms produced, TA is believed to be closely related to other cellulose biosynthesis inhibitors (CBIs) such as isoxaben (IXB) and dichlobenil (DCB) [5]. The linkage of the modes of actions of these compounds has been confirmed with habituation studies to TA, ...
Based on similarity of symptoms produced, TA is believed to be closely related to other cellulose biosynthesis inhibitors (CBIs) such as isoxaben (IXB) and dichlobenil (DCB) [5]. The linkage of the modes of actions of these compounds has been confirmed with habituation studies to TA, ...