Detailed cell wall biosynthetic pathway is described as four major steps involving several enzymes. Fructose-6-phosphate from glycolysis serves as precursor for initiating cell wall synthesis in the cytoplasm. This is first converted to uridyl conjugate of N-acetyl glucosamine which converts to N-...
Inhibition of the Bacterial Cell Wall Synthesis in vitro by Enduracidin, a New Polypeptide Antibiotic MATSUHASHI Michio , OHARA Ikuko , YOSHIYAMA Yoshihiro Bioscience, Biotechnology, and Biochemistry 33(1), 134-137, 1969doi:10.1080/00021369.1969.10859291MATSUHASHI Michio...
Protein Synthesis Inhibitors and Bacterial Susceptibility to Phagocytosis It is well recognised that antibiotics can be either bactericidal or bacteriostatic and on this basis their therapeutic efficacy can be measured. In particular those drugs in the latter category may depend upon the underlying ...
It was demonstrated that inhibition of Ddl directly produces a significant loss of strength of the bacterial cell wall and, as a result, a more likely disruption of the bacterial cell [11]. Hence, Ddl inhibitors have become attractive agents and hot spots for the development of new ...
We also tested two other cell-wall synthesis inhibitors, fosfomycin and mecillinam. Fosfomycin inhibits MurA, the enzyme catalyzing the first committed step of peptidoglycan biosynthesis34,35, and mecillinam specifically targets PBP2, a transpeptidase that crosslinks new cell-wall material36. In both...
Undecaprenyl pyrophosphate synthase is a cis -prenyltransferase enzyme, which is required for cell wall biosynthesis in bacteria. Undecaprenyl pyrophosphat... W Sinko,CD Oliveira,S Williams,... - 《Chemical Biology & Drug Design》 被引量: 76发表: 2011年 Inhibitors of phosphopantetheine adenylyltran...
De novo synthesis of dihydrofolate is unique for several microorganisms, parasites and plants. The synthetic pathway of dihydrofolate is therefore a suitable target for specific inhibitors. To optimize inhibitors for specific biological systems, detailed quantitative structure-activity relationships (QSAR) hav...
Studies on bacterial cell wall inhibitors. VI. Screening method for the specific inhibitors of peptidoglycan synthesis A screening method was established for selecting new specific inhibitors of bacterial cell wall peptidoglycan synthesis. In the primary test, culture broths of soil isolates were selected...
a cellulose-deficient mutant inS. Enteritidis was previously reported to be more sensitive to chlorine53. Overall, these results indicate that EPS production enhances biofilm functioning by both increasing cell numbers and tolerance to antimicrobials, which supports the idea of EPS inhibitors as an anti...
D. 1963. Amino acid deprivation and bacterial cell wall synthesis. Trans. N.Y. Acad. Sci. 26:182-195.SHOCKMAN GD. AMINO-ACID DEPRIVATION AND BACTERIAL CELL-WALL SYNTHESIS. Trans N Y Acad Sci. 1963 Dec; 26 :182–195.Shockman, G. D.: Amino acid deprivation and bacterial cell wall ...