RNA INTERFERENCE MEDIATED INHIBITION OF ISOCITRATE DEHYDROGENASE (IDH1) GENE EXPRESSIONThe present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of IDH1 and mutant IDH1 gene expression ...
Gabriel I , Vetter ND , Palmer DRJ , Milewska MJ , Wojciechowski M & Milewski S ( 2013 ) Homoisocitrate dehydrogenase from Candida albicans : properties, inhibition, and targeting by an antifungal pro-drug . FEMS Yeast Res 13 : 143 – 155 ....
Mutation at the R132 residue of isocitrate dehydrogenase 1 (IDH1), frequently found in gliomas and acute myelogenous leukemia, creates a neoenzyme that produces 2-hydroxyglutarate (2-HG) from α-ketoglutarate (α-KG). We sought to therapeutically exploit this neoreaction in mutant IDH1 cells that...
Nonalcoholic fatty liver disease (NAFLD) and its evolution to inflammatory steatohepatitis (NASH) are the most common causes of chronic liver damage and transplantation that are reaching epidemic proportions due to the upraising incidence of metabolic sy
Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1 Article Open access 01 November 2021 Accelerating inhibitor discovery for deubiquitinating enzymes Article Open access 08 February 2023 Manumycin polyketides act as molecular glues between UBR7 and P53...
isocitrate dehydrogenase-2 inhibitor1. The present study investigated inhibitory effects of enasidenib and its metabolite AGI-16903 on (a) recombinant human nucleoside transporters (hNTs) in hNT-producing Xenopus laevis oocytes, and (b) azacitidine uptake in normal B-lymphoblast peripheral blood cell ...
Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents. December 01, 2023 [MEDLINE Abstract] Discovery of coumaric acid derivatives hinted by coastal marine source to seek for uric acid lowering agents. ...
Isocitrate Dehydrogenase Mutations Induce BCL-2 Dependence in Acute Myeloid Leukemia through Inhibition of Cytochrome C Oxidase Function IDH1 and IDH2 are two of the most frequently mutated genes in acute myeloid leukemia at an overall frequency of about 15-20%. The genes encode enzymes in the cit...
Isocitrate dehydrogenase 2 IVIS: In-vivo imaging system LRP6: Low density lipoprotein receptor-related protein 6 NPM1: Nucleophosmin 1 NSG: NOD/SCID gamma RAC1: Rac family small GTPase 1 TCF/LEF: T-cell factor/lymphoid enhancer factor
Regulation of brefeldin A-induced ER stress and apoptosis by mitochondrial NADP-dependent isocitrate dehydrogenase. Biochem Biophys Res Commun 2012; 417: 760–764. Article CAS Google Scholar Than TA, Lou H, Ji C, Win S, Kaplowitz N . Role of cAMP-responsive element-binding protein (CREB)-...