Soundar, S., Park, J.-H., Huh, T.-L. & Colman, R. F. Evaluation by mutagenesis of the importance of 3 arginines in α, β, and γ subunits of human NAD-dependent isocitrate dehydrogenase. J Biol Chem 278, 52146-52153 (2003)....
A preliminary survey of 17 enzyme systems revealed nine polymorphic resolvable loci. The following seven enzyme systems encoded by nine presumptive loci were scored in all six populations: fumarate hydratase (FUM); isocitrate dehydrogenase (IDH, two loci: fast and slow [s]); malate dehydrogenase (...
We determined the prevalence of the mutated isocitrate dehydrogenase (mIDH) using The Cancer Genome Atlas (TCGA).#We identified 1980 patients with DA. For frontal DAs, GTR resulted in improved survival relative to subtotal resection in all ages (age ≤50 years hazard ratio [HR], 0.56; P= ...
1.2.3.14. Inhbition of isocitrate lyase enzyme A number of bromophenols isolated from the red alga Odonthalia corymbifera exhibited potent inhibitory activity against isocitrate lyase, an important enzyme in the rice fungal pathogen, Magnaporthe grisea. The compounds 3,5-dibromo-4-hydroxyphe-nyleth...
IDHIn 2016, the WHO incorporated molecular markers, in addition to histology, into the diagnostic classification of central nervous system (CNS) tumours. This improves diagnostic accuracy and prognostication: oligo-astrocytoma no longer exists as a clinical entity; isocitrate dehydrogenase (IDH) mutant ...
Immunohistochemistry showed an absence of CD34 expression, whereas isocitrate dehydrogenase 1 (IDH1) was positive in the glial component. Moreover, IDH1 was positive in the ganglion-like cells as well as in the glial component. Subsequent 1p/19q co-deletion was confirmed by fluorescence in situ ...
isocitrate dehydrogenasePII proteinPII protein.Ammonium is the reduced nitrogen form available to plants for assimilation into amino acids. This is achieved by the GS/GOGAT pathway that requires carbon skeletons in the form of 2‐oxoglutarate. To date, the exact enzymatic origin of this organic ...
Glycerolphosphate DehydrogenaseIsocitrate DehydrogenaseStave U.doi:10.1111/j.1440-169X.1967.tb00234.xStave UEnzymol Biol Clin (Basel)Enzymologia Biologica Et ClinicaStave, U., 1967, Importance of proper substrate concentrations for enzyme assays in tissue homo-genates for developmental studies, Enzymol...
Targeting of cell metabolism in human acute myeloid leukemia—More than targeting of isocitrate dehydrogenase mutations and PI3K/AKT/mTOR signaling? Eur. J. Haematol. 2016, 96, 211–221. [CrossRef] [PubMed] Molecules 2016, 21, 1512 23 of 32 26. Lee, J.J.; Loh, K.; Yap, Y.S. ...