Inhibition of dihydroorotate dehydrogenase (DHO-DH) is the molecular mechanism of immunosuppression by malonitrilomides (MNAs) in vivo. Intl Soc Heart Lung Transplant 18th Ann Mtg 1998, April 15-18, 1998, Chicago, IL, USA:102.
In particular, we are interested in evaluating the enzyme dihydroorotate dehydrogenase (DHODH) as a drug target. DHODH is a flavoenzyme that catalyzes the stereospecific oxidation of (S)ヾihydroorotate (DHO) to orotate during the fourth and only redox step of the de novo pyrimidine nucleotide ...
POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase Yanmei Peng, Wenbo Zheng, Yuehong Chen, Xuetao Lei, Zhijing Yang, Yuxuan Yang, Weiqi Liang, Kai Sun, Guoxin Li & Jiang Yu Cell Death & Diseas...
Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosisHeT.Haapa-PaananenS.KaminskyyV.O.KohonenP.FeyingentaconnectOncogene BasingstokeHe T, Haapa-Paananen S, Kaminskyy VO, Kohonen P, Fey V...
The ability of A77 1726 to inhibit the activity of dihydroorotate dehydrogenase (DHO-DHase), a rate-limiting enzyme in pyrimidine nucleotide synthesis, is about 10 to 100 times more potent than its ability to inhibit the activity of protein tyrosine kinases such as p56lck, p59fyn, and PDGF...
Castration-resistant prostate cancer (CRPC) is an aggressive disease with poor prognosis, and there is an urgent need for more effective therapeutic targets to address this challenge. Here, we showed that dihydroorotate dehydrogenase (DHODH), an enzyme crucial in the pyrimidine biosynthesis pathway, ...
The antiviral activity of FK778 was reversed in cell culture by treatment with uridine, consistent with specific inhibition of dihydroorotate dehydrogenase (DHODH), a required enzyme in the de novo biosynthesis of pyrimidines. This report substantiates the clinical possibility of a single drug ...
Brequinar sodium (DUP-785; Brequinar) is a potent inhibitor of the pyrimidine de novo enzyme dihydroorotate dehydrogenase (DHO-DH), leading to a depletion ... G,J,Peters,... - 《British Journal of Cancer》 被引量: 34发表: 1992年 In vitro studies on the inhibition of colon cancer by ...
For these compounds, no mutations were found that caused IC50 increases as high as those that earlier proved problematic (30-fold or higher) in human clinical trials with inhibitors targeting dihydroorotate dehydrogenase (DHODH) or the sodium-dependent ATPase PfATP4.30,32 Unlike other classes of ...
The suppression was dependent on the p53 response, which is triggered by the impairment of the complex III-dependent de novo biosynthesis of pyrimidines by mitochondrial dihydroorotate dehydrogenase. The initial adaptive induction of ATF4/ISR acted to promote viability of cells by attenuating apoptosis....