Inflammatory bowel disease (IBD) is an idiopathic and persistent inflammatory illness of the bowels, leading to a substantial burden on both society and patients due to its high incidence and recurrence. The pathogenesis of IBD is multifaceted, partly attributed to the imbala...
The discovery of peculiar inflammatory bowel disease-associated microbial strains will not only shed new light on inflammatory bowel disease aetiogenesis, they may also support the development of novel therapeutic strategies not merely treating symptoms, but precisely counteracting the primary cause of ...
For Santamaria’s team, these results suggest that cytotoxic T cells against specific microbial epitopes might be useful in treating inflammatory bowel disease. “We are interested in studying how the T cell response to the gut microbiome can be harnessed for therapeutic purposes, as well as in ...
CHICAGO, Aug. 19 (Xinhua) -- Researchers at the University of Michigan (UM) have developed a nanoparticle that alters the gut microbiome and alleviates symptoms of inflammatory bowel disease in mice more effectively than common FDA-approved medications. The nanoparticles consist of two naturally occu...
Inflammatory bowel disease (IBD) is the general term used to indicate two chronic and relapsing immune-mediated diseases of the gut, namely, Crohn's disease (CD) and ulcerative colitis (UC). CD develops mostly in the terminal ileum and colon but can involve all the portions of the alimentary...
Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore, eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase and superoxide dismutase may effectively curb inflammatory bowel disease (IBD). Here, E
The association between the gut microbiota and the inflammatory bowel disease activity: a systematic review and meta-analysis Background: The pathogenesis of inflammatory bowel diseases (IBD) involves complex interactions between the microbiome and the immune system. We evaluated ... M Prosberg,F Bend...
et al. Dynamics of metatranscription in the inflammatory bowel disease gut microbiome. Nat. Microbiol.3, 337–346 (2018). CAS PubMed PubMed Central Google Scholar Schirmer, M. et al. Linking the human gut microbiome to inflammatory cytokine production capacity. Cell167, 1897–1897 (2016). ...
A. et al. Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nat. Microbiol. 4, 293–305 (2019). This paper reports metagenomic and metabolomic profiling of cross-sectional stool samples from IBD cohorts to identify associations between intestinal bacteria and metabolites ...
Dynamics of metatranscription in the inflammatory bowel disease gut microbiome Inflammatory bowel disease (IBD) is a group of chronic diseases of the digestive tract that affects millions of people worldwide. Genetic, environmental and microbial factors have been implicated in the onset and exacerbation...