Disruption of tissue function activates cellular stress which triggers a number of mechanisms that protect the tissue from further damage. These mechanisms involve a number of homeostatic modules, which are regulated at the level of gene expression by the transactivator NF-κB. This transcription facto...
Matrigel-infiltrating macrophages required (i) the presence of Id-specific CD4+T cells and (ii) the local production of Id antigen. This observation suggests that the antitumour immune response may be very similar against MOPC315 and F9 cells, although the two cell types differ in terms of MH...
This review examines recent advances and underlying mechanisms of inflammation in obesity, T2D, and related disorders. We describe how this chronic tissue inflammation includes multi-organ cross-talk causing IR, impaired insulin secretion, glucose intolerance, and T2D. We also review the effect of inf...
Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from tumor development, invasion, and metastasis to the resistance of tumors to treatment. Inflamma...
may inform disease progression. To test this hypothesis, we identified genes that are differentially expressed in the tumor or TAN tissue between the group of patients that eventually progress and the ones that do not. More specifically, patients from our matched tumor-normal cohort were divided in...
early, intermediate, or late, reflecting differential time course and differential magnitude of change in response to the APR ○ type 1, stimulated by TNF and/or IL-1, or type 2, stimulated by IL-6 Acute inflammation: • A physiologic response to infection or tissue injury that is usually...
tissue. Here, we summarized current understanding of the different subsets of major immune cells, including T cells, B cells, dendritic cells, monocytes, and macrophages. We highlighted molecular characterization, frequency, and tissue distribution of these immune cell subsets in human and mice. In ...
This cohort study evaluates whether higher levels of certain inflammatory markers during pregnancy are associated with preterm birth, low birth weight,
The infrapatellar fat pad and other adipose tissues in close proximity to the joint have been linked with osteoarthritis (OA), but the nature of this relationship is unclear. Two new studies elucidate the features of intra-articular adipose tissues in OA
The single-cell suspensions of the LNs were prepared by following the procedure for DC isolation. LN cells were plated in tissue culture plates and pulsed with soluble A647-OVA or A647-OVA-IC (equivalent to 1 μg OVA per LN) for 1 h. DCs that took up OVA were assessed as A647...