The spatiotemporal regulation of immune cells in lymph nodes (LNs) is crucial for mounting protective T-cell responses, which are orchestrated by dendritic cells (DCs). However, it is unclear how the DC subsets are altered by the inflammatory milieu of LNs. Here, we show that the inflamed ...
Different cell components are involved in the development of inflammation, including neutrophils, mastocytes, T and B lymphocytes, and monocytes/macrophages. Activation of these cells leads to the production of cytokines and mediators responsible for inflammation. More specifically, monocytes/macrophages ha...
Role of γ/δ T cells in rheumatoid inflammation J Kjeldsen‐Kragh,AJ Quayle,Y Frre - 《Arthritis & Rheumatology》 被引量: 0发表: 1992年 Role of B Cells in the Pathogenesis of Rheumatoid Arthritis In patients with rheumatoid arthritis, chronic inflammation in affected joints may lead to the...
Leukocytes express chemokine receptors that, upon ligand recognition, are believed to activate and induce the directed migration of these cells from the va... Michelle L Rand, Jeffrey S Warren, Michael K Mansour, Walter Newman, Douglas J Ringler - 《American Journal of Pathology》 被引量: 236...
inflammation and immune response function [23]. Our recent single-cell RNA-seq study which determined the functional impact of theCcm3deletion in endothelial cells further showed that it is mainly endothelial cells of venous/venous capillary and tip cell origin that had altered immune response ...
The relationship between inflammation of hyperreactivity of the airways in asthma 来自 NCBI 喜欢 0 阅读量: 36 作者:ID Chapman,A Foster,J Morley 摘要: Author information: (1)Preclinical Research, Sandoz Pharma Ltd, Basel, Switzerland.关键词: GROWTH FACTORS IMMUNE RESPONSE INFLAMMATION IMMUNE CELLS ...
Inflammation is a central feature of liver fibrosis as suggested by its role in the activation of hepatic stellate cells leading to extracellular matrix deposition. During liver injury, inflammatory cells are recruited in the injurious site through chemokines attraction. Thus, inflammation could be a ...
Interleukin 17A, a cytokine produced by TH17 and other immune cells, plays a crucial role in the defense against various microbial pathogens. While the reasons for increased PTB with IL-17A are unclear, higher levels of IL-17A associated with excess inflammation can result in tissue damage. In...
Inflammation is a beneficial host response to infection but can contribute to inflammatory disease if unregulated. The Th17 lineage of T helper (Th) cells can cause severe human inflammatory diseases. These cells exhibit both instability (they can cease
cells that modulate basic functions that are important for the early steps in inflammation, such as immune cell migration into inflamed tissues and immune cell differentiation. In chronically inflamed tissues, aberrant ECM expression and fragments of the ECM that are derived from tissue-remodelling ...