Inflammatory cells release cytokines and growth factors, which stimulate mesenchymal cells including fibroblasts and myofibroblasts to create ECM components such as collagen [32]. This short-lived ECM deposition serves as a provisional scaffold for tissue healing and aids in the restoration of intestinal...
Cell death plays an important role in the regulation of inflammation and may be the result of inflammation. The maintenance of tissue homeostasis necessitates both the recognition and removal of invading microbial pathogens as well as the clearance of dying cells. In the past few decades, emerging...
Figure 2.Pathways to labour. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns; NF-κB: nuclear factor kappa light chain enhancer of activated B cells; cfDNA: cell-free DNA. Created withBioRender.com(accessed on 3 February 2022). ...
1.1. The Functioning of Hematopoietic Stem Cells Declines with Age Multiple aging-associated hematopoietic features occur in both peripheral blood (PB) and bone marrow (BM). Aged mice display elevated platelet counts [1,2,3] and myeloid cells [4], with concomitant decreased red blood cells (RBC...
B. Accelerated aging in HIV/AIDS: novel biomarkers of senescent human CD8+ T cells. PLoS One 8, e64702 (2013). Article CAS PubMed PubMed Central Google Scholar Sochocka, M., Zwolińska, K. & Leszek, J. The infectious etiology of Alzheimer’s disease. Curr. Neuropharmacol. 15, 996...
ST-HSC, short-term haematopoietic stem cells; MegE, megakaryocyte-erythrocyte; MEP, megakaryocyte-erythrocyte progenitor; GM, granulocyte-monocyte. b, Heatmap of the number of distal peaks that were open or closed in CMPs (open, 8,753 in Daxx-KO and 18,194 in Daxx-WT cells; closed, 28,...
Intrauterine infection/inflammation can result in fetal and neonatal lung injury. However, the biological mechanisms of intrauterine infection/inflammation on fetal and neonatal lung injury and development are poorly known. To date, there are no reliable
The role of inflammation in T2DM Individuals at risk for type 2 diabetes exhibit hypersecretion of insulin in their β-cells, compensating for their initial state of insulin resistance. As the disease progresses, this functional reserve of the pancreas eventually depletes, paving the path for the...
While short-term adaptive inflammatory reactions facilitate tissue repair, engaging a variety of cells, organs, and complex signaling pathways, chronic inflammation can lead to sustained tissue damage and exacerbate disease states [3] For example, in myocardial infarctions and cerebrovascular accidents, ...
The role of inflammation and infection in preterm birth. Semin Reprod Med. 2007;25(1):21-39. doi:10.1055/s-2006-956773 PubMedGoogle ScholarCrossref 4. Peltier MR. Immunology of term and preterm labor. Reprod Biol Endocrinol. 2003;1:122. doi:10.1186/1477-7827-1-122Pub...