indolin-3-onestetrahydro-4-quinolonesSynthetic MethodsHeterocyclic compounds that contain indolin-3-one and tetrahydro-4-quinolone skeletons have received much attention because these motifs are widespread in naturally occurring bioactive materials. In their Communication on Page130ff. featured on the ...
Abonia R, Cuervo P, Castillo J, Insuasty B, Quiroga J, Nogueras M, Cobo J (2008) Unexpected intramolecular cyclization of some 2'-aminochalcones to indolin-3-ones mediated by amberlyst (r)- 15. Tetrahedron Lett 49(34):5028-5031
An efficient silver triflate-catalyzed tandem hydroamination/hydroarylation cascade generating 1'-allylspiro[indene-1,2'-indolin]-3'-ones from 1-(2-allylamino)phenyl-4-hydroxy-but-2-yn-1-ones is described. The reaction conditions are mild and general in scope and proceed to highly functionalize...
3-Piperidino-2-hydroxypropoxy substituted-2-indolinonesThis invention provides new compounds of formula I, ##STR1## wherein Het is a radical formed by removing one of the hydrogens from the phenyl ring of 2-indolinone or fluorenone, andR is the group A, B, C or D, ##STR2## where...
One-Pot Synthesis of Indolin-3-ones Mediated by LiN(SiMe 3 ) 2 /CsF Download: Download high-res image (52KB) Download: Download full-size imageRuyuan MaYuanyun GuYan-En WangRongbi FeiDan XiongJianyou Mao
The present invention relates to indolinones substituted in the 6-position of general formula wherein Rto Rand X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inh...
hydroxyindolin-2-oneisatinAn efficient and greener protocol for easy access to 3-susbstituted-3-hydroxy-2-oxindoles by the reaction with various substituted isatins and acetophenones is described. This protocol is widely applicable for a variety of isatins and acetophenones using water as a ...
An efficient and mild procedure for the synthesis of spiro[1,4,2-dioxazinan]oxindoles has been achieved in high yields by [Formula: see text]-catalyzed annulation of 3-oxirane-indolin-2-ones and nitrones. This catalytic protocol demonstrates that the reaction could tolerate a variety of funct...
The first asymmetric [4 + 3] cycloaddition of hydroxyphenyl indolinones has been reported to afford a new series of multisubstituted spirooxindole derivatives embedded with an oxadiazepine scaffold with high stereoselectivities. The reaction proceeds via o -QM intermediates produced in situ from hydrox...
Including indanones, indolinones and benzoxazolinones containing a piperidine ring, e.g., 1-[3-(4-(Hydroxymethyl)piperidin-1-yl)propyl]-1,3-dihydrobenzoimidazol-2-one; particularly for the M1 and/or M4 receptor subtypes; increase acetylcholine signaling or effect in the brainUS 7291611 B2 ...