-position of the imines are transformed into indolin-3-ones by a reductive cyclization by using bis(trimethylsilyl) aluminum chloride. The synthesis of trisubstituted tetrahydro-4-quinolones was also developed by a 1,3-aza-Brook rearrangement/Dieckmann condensation of ...
Abonia R, Cuervo P, Castillo J, Insuasty B, Quiroga J, Nogueras M, Cobo J (2008) Unexpected intramolecular cyclization of some 2'-aminochalcones to indolin-3-ones mediated by amberlyst (r)- 15. Tetrahedron Lett 49(34):5028-5031
Indolinones of Formula II above may be prepared by cyclization of the corresponding alpha-chloro diphenyl amide. Nitriles of Formula IV above are prepared by reaction of a compound of Formula II above with a halide of Formula Hal-(C n-1 H 2n-2 )CN. Halides of Formula VI above are ...
3-取代吲哆酮1. Study structure-activity relationship of 3-substituted indolin-2-ones antitumor activities on quantum chemistry; 用量子化学研究3-取代吲哆酮类化合物抗肿瘤活性的构效关系2) 3-subsituted-2-indolinone 3-取代2-吲哚酮 3) 3-substituted indolin-2-one 3-取代吲哚-2-酮 1. In...
This invention provides new compounds of formula I, ##STR1## wherein Het is a radical formed by removing one of the hydrogens from the phenyl ring of 2-indolinone or fluorenone, and R is the grou
Under the catalysis of 1 mol% of Br 2 or HBr at room temperature, indoles undergo a rapid reaction with 3-hydroxy-3-(indol-3-yl)indolin-2-ones to give asymmetric 3,3-di(indol-3-yl)indolin-2-ones with high efficiency and wide substrate scope. This is a ra
理解Baylis-Hillman反应的范围:3-(2-羟苯基)吲哚-2-酮和多环稠合呋喃的合成 通过TiCl4介导的N-取代的靛红与环己-2-烯酮的Baylis-Hillman(B-H)反应,已经开发出一种简便的一锅合成3-(2-羟苯基)吲哚-2-酮的方法,随后通过用HBr水溶液处理原位生成的B–H醇来解决。在TiCl4的影响下,芳香环1,2-二酮与环烷...
Organocatalytic Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Azlactones and Methyleneindolinones† Angewandte Chemie Pub Date : 1 July 2013 , DOI: 10.1002/ange.201302831 Wangsheng Sun , Gongming Zhu , Chongyang Wu , Guofeng Li , Liang Hong , Rui Wang Ein einfacher Weg zu ...
Accordingly, the impact of 1-benzyl-5-bromoindolin-2-one derivative 7d on caspase 3 was evaluated. Being the executioner caspase, its induction gives insight into the pro-apoptotic effect of 7d. Moreover, the effect of 7d on the activation of caspase-9 was determined for further evaluation ...
Including indanones, indolinones and benzoxazolinones containing a piperidine ring, e.g., 1-[3-(4-(Hydroxymethyl)piperidin-1-yl)propyl]-1,3-dihydrobenzoimidazol-2-one; particularly for the M1 and/or M4 receptor subtypes; increase acetylcholine signaling or effect in the brainUS 7291611 B2 ...