tetrahydro-4-quinolonesBringing closure: -Imino esters that contain alkoxycarbonyl electron-withdrawing groups at the -position of the imines are transformed into indolin-3-ones by a reductive cyclization by using bis(trimethylsilyl) aluminum chloride. The synthesis of trisubstituted tetrahydro-4-...
To determine if the RTKs inhibited by 47 contributed to the observed biological effects, the potential targets of IGF-1R, EphA2 and Tyro3 were silenced by the siRNA approach and the effect on apoptosis was measured. Four siRNA sequences were tested for each gene and the ones with the best...
The hapalindole-type family of natural products is a group of hybrid isoprenoid-indole alkaloids, produced solely by members of the Subsection V cyanobacterial strains. This family broadly includes the hapalindoles, welwitindolinones, fisherindoles and a
?zsoy, NurtenCan, Ay?ePubMedJournal of Enzyme Inhibition & Medicinal ChemistryGorkem, E., Karali N., Ozsoy, N., Can, A., New spiroindolinones bearing 5-chlorobenzothiazole moiety, J. Enz. Inh. Med. Chem. (2013) (early online)...
70.* REACTIONS OF 2-AMINOMETHYLENEINDOLIN-3-ONE WITH CH-ACIDS. SYNTHESIS OF SUBSTITUTED PYRROLO ['I,2-a]INDOLES S. Yu. Ryabova, L. M. Aiekseeva, and V. G. Granik UDC 547.755:547.741 The reaction of enaminoketones, 2-dimethylamino- and piperidinomethyleneindolin-3-ones with dimedone ...
Indolinones of Formula II above may be prepared by cyclization of the corresponding alpha-chloro diphenyl amide. Nitriles of Formula IV above are prepared by reaction of a compound of Formula II above with a halide of Formula Hal-(C n-1 H 2n-2 )CN. Halides of Formula VI above are ...
Substituted indolinones can be referred as ‘privileged structures’ owing to their excellent binding affinity for many receptors and to the number of approved drugs containing this scaffold[1]. Oxindole has been found in tissues and fluids of mammals as well as natural products produced by a ...
98. No. 3, pp 885-887). WO 01/60814 discloses pyrrole substituted 2-indolinone derivatives bearing certain amido substituents directly attached to the pyrrole ring as receptor tyrosine kinase inhibitors. WO 02/055517 discloses indolinones substituted with aryl substituents at the 4 position ...
The present invention relates to 5'-indolinyloxazolidin-2-ones (XI) ##STR1## 3-(fused-ring) substituted)phenyl-5β-amidomethyloxazolidin-2-ones (XXI) ##STR2## and 3-(nitrogen substituted)phenyl-5β-amidomethyloxazolidin-2-ones (LV) which are useful as antibacterial agents and the inter...
tuted-2-indolinones 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones3-Piperidino-2-hydroxypropoxy substituted-2-indolinonesThis invention provides new compounds of formula I, ##STR1## wherein Het is a radical formed by removing one of the hydrogens from the phenyl ring of 2-indolin...