Ambenonium chloride is a fast-acting indirect cholinergic agonist that inhibits the regulation of acetylcholinesterase activity, thereby inhibiting acetylcholine hydrolysis and increasing its activity on nicotinic receptors in neuromuscular interactions. IsоfluоrрhаteMechanism of Аction- Isоflurорh...
Furthermore, these two drugs completely blocked the increase in striatal acetylcholine produced by the dopamine receptor agonist, apomorphine, and had no effect on striatal choline acetyltransferase and cholinesterase. These data suggest that haloperidol and pimozide act on the striatal cholinergic neurons ...
(0.02 mg kg-1 h-1) via subcutaneously implanted osmotic minipumps from day 1 to 7. To specifically block the D3receptor, we used BP 897, a D3receptor-selective partial agonist with an intrinsic activity of ~0.5 in a heterologous expression system (Pilla et al.1999), which also ...
The rapid progress in the area of molecular biology has provided us with the primary structures of a large variety of receptor proteins, many of which belong to the G-protein coupled receptor super family (e.g., dopamine (DA) D1and D2receptors, serotonin (5-HT) 5-HT1A, 5-HT1Cand 5-...