Cholinergic agonist and antagonist drugs modulate the growth hormone response to growth hormone-releasing hormone in the rat: evidence for mediation by som... Recently, data have been presented showing that muscarinic cholinergic agonists or antagonists can modulate, in opposite ways, GH-releasing hormo...
Prado WA, Corrado AP (1987) Cholinergic agonist and antagonist interactions on motor nerve end- ings of the rat: Evidence for the involvement of presynaptic receptors in the regulation of ace- tylcholine release. Gen Pharmacol 18:75-81.
Confirming the early studies of Jouvet and Raul Hernandez-Peon, numerous investigations have found prompt and sustained increases inREM sleepsigns when cholinergicagonistdrugs are microinjected into the pontinebrain stemof cats. The behavioral syndrome produced by this treatment is indistinguishable from th...
The effects of the drugs on agonist-induced isometric contractions and depolarizations were studied. Logarithmic plots of (dose ratio–1) against antagonist concentration yielded regressions with slopes greater than unity when monoquaternary antagonists were used, and less than unity when bisquaternary ...
Acetylcholine regulates various cognitive functions through broad cholinergic innervation. However, specific cholinergic subpopulations, circuits and molecular mechanisms underlying recognition memory remain largely unknown. Here we show that Ngfr+ choli
Reduction in fear response is rescued by the GABA antagonist picrotoxin in mutant mice, and, in wild-type mice, is mimicked by the GABA agonist midazolam suggesting that GABA can modulate cholinergic functions on fear circuitries. Importantly, mutant mice also show a reduction in fear processing...
Scopolamine was equipotent in both brain regions and did not discriminate subtypes of 3H-QNB binding. By contrast, the M1 selective antagonist pirenzepine was approximately 33-fold more potent in human cortex than pons. Carbachol, a putative M2 selective agonist, was more than 100-fold more ...
[154]. The ECD contains the binding site for the agonist. The TMD has four hydrophobic areas designated M1, M2, M3, and M4, among which, M2 forms the inner lining of the ion channel and has an affinity for cations due to containing more acidic amino acid residues [155]. As compared ...
Cholinergic stimulation with the α7nAChR agonist DMXBA significantly alleviated CRS-induced depressive-like behavior, neuroinflammation, and neuronal damage, but these effects were abolished by the selective α7nAChR antagonist α-bungarotoxin. Furthermore, activation of α7nAChRs restored the central ...
However, infusion of the nAChR antagonist mecamylamine (100 μM) did not block the hypothermic effect of optical stimulation of DMH cholinergic neurons (Figure 4G, I, and J, n = 6 animals). As stimulation of DMH cholinergic neurons decreases BAT activity, we further sought to determine ...