In the hypohidrotic area, where pinpoint wheal occurs, it is hypothesized that released Ach cannot be completely trapped by cholinergic receptors of eccrine glands and overflows to the adjacent mast cells, lead
An indirect-acting agonist exerts its action by increasing the concentration of the endogenous compound (e.g., by affecting vesicular storage or release of a neurotransmitter) that then activates the receptor. The potency of an agonist in vitro is typically expressed as its KD or KI, estimated ...
This article, based on original data as well as on previously reported preclinical and clinical data that are reviewed, describes direct and indirect inter
was not found to have significant anti-atheromatous effects, although it did reduce hepatic triglyceride levels, suggesting an indirect mode of action [97]. DPP-4 inhibitors have also been shown to have anti-inflammatory actions. Recent studies have demonstrated direct suppression of aortic atheroscler...
To discover candidate drugs to repurpose for COVID-19 using literature-derived knowledge and knowledge graph completion methods. Methods We propose a novel, integrative, and neural network-based literature-based discovery (LBD) approach to identify drug candidates from PubMed and other COVID-19-focus...
Dannenberg H, Pabst M, Braganza O, Schoch S, Niediek J, Bayraktar M, Mormann F, Beck H. Synergy of direct and indirect cholinergic septo- hippocampal pathways coordinates firing in hippocampal networks. J Neu- rosci 35: 8394 - 8410, 2015....
was not found to have significant anti-atheromatous effects, although it did reduce hepatic triglyceride levels, suggesting an indirect mode of action [97]. DPP-4 inhibitors have also been shown to have anti-inflammatory actions. Recent studies have demonstrated direct suppression of aortic atheroscler...
than others; for some, the currently available data are quite fragmentary. The pharmacology will be reviewed here in terms of specific signaling molecules. Arguably because of direct or indirect extensions to children, the greatest advances so far have been made in cholinergic anddopaminergic...
These studies revealed that in parkinsonian mice, the functional connectivity of PFn neurons with indirect pathway SPNs (iSPNs) was selectively enhanced by cholinergic interneurons acting through presynaptic nicotinic acetylcholine receptors (nAChRs) on PFn terminals. Attenuating this network adaptation by ...
It is in the nonselective, irreversible antagonist of the alpha-adrenergic receptors class of drugs [40]; Atropine competitively blocks the effects of acetylcholine, including excess acetylcholine due to organophosphorus poisoning, at muscarinic cholinergic receptors on smooth muscle, cardiac muscle, ...