C-type inactivation underlies important roles played by voltage-gated K + (Kv) channels. Functional studies have provided strong evidence that a common underlying cause of this type of inactivation is an alteration near the extracellular end of the channel's ion-selectivity filter. Unlike N...
Crystal structure of a voltage-gated sodium channel in two potentially inactivated states. In excitable cells, voltage-gated sodium (Na(V)) channels activate to initiate action potentials and then undergo fast and slow inactivation processes that... P Jian,TMG El-Din,T Scheuer,... - 《Nature...
Existing evidence shows that LGI1 prevents the inactivation of the voltage-gated potassium channel Kv19 and regulates the pruning and synaptic transmission of glutamatergic synapses in the hippocampus5,7,10. The refined synaptogenesis might be mediated by the binding of LGI1 to transmembrane ADAM (...
Additionally, this report describes the detailed, three-dimensional models we have developed for the entire transmembrane region and important functional sites of the voltage-gated Shaker K+ channel in the open, closed, and inactivated conformations (including the ion-selective pore ...
The voltage-gated potassium channel KV1.3 is an important therapeutic target for the treatment of autoimmune and neuroinflammatory diseases. The recent structures of KV1.3, Shaker-IR (wild-type and inactivating W434F mutant) and an inactivating mutant of rat KV1.2-KV2.1 paddle chimera (KVChim-W...
Gem stabilizes voltage-gated calcium channels in the inactivated state: implications for human disease. Biophys J, 2012, 102: 431aGem Stabilizes Voltage-Gated Calcium Channels in the Inactivated State: Implications for Human Disease[J] . Zafir Buraei,Rose Levenson-Palmer,Scott Dobbins,Jian Yang....
Autoimmune encephalitis associated with voltage-gated potassiumchannels-complex and leucine-rich glioma-inactivated 1 antibodies a national cohort study. Eur J Neurol. 2017;24:999-1005.Celicanin M, Blaabjerg M, Maersk-Moller C, et al. Autoimmune encephalitis associated with voltage-gated potassium ...
Background and purposeThe aim of this study was to describe clinical and paraclinical characteristics of all Danish patients who tested positive for anti-voltage-gated potassium channels (VGKC)-complex, anti-leucine-rich glioma-inactivated 1 (LGI1) and anti-contactin-associated protein-2 antibodies...
The results show that the stack of ion binding sites (S1 to S4) in the inactivated filter models remain accessible to cations as they are in the resting channel state. The inactivated state of the selectivity filter is therefore "resting-like" under such equilibrium conditions. Nonetheless, ...