Virtually, voltage-gated sodium (Na+) channels are expressed in all electrically excitable tissues and are essential for muscle contraction, and conduction of impulses within the peripheral as well as central nervous systems. Genetic disorders that disrupt the function of voltage-gated sodium (Na+) ...
Voltage-gated Na+ (NaV) channels are key mediators of neuronal function and essential for neuronal excitability. Their abnormal activity is implicated in the generation of seizures, both in acquired and genetic epilepsy. Several of the most widely used antiepileptic drugs inhibit NaV activity by ...
The subtype composition, density and distribution of voltage-gated Na+ channels determine the property of the various types of neurons or the specific areas of each neuron26. Also, expression and distribution of the different members of the voltage-gated Na+channel family at the subcellular...
Brugeaud A, Lehouelleur J, Couraud F, Valmier J, Sans A (2003) Voltage-gated Na � channel activation induces both action potentials in utricular hair cells and brainderived neurotrophic factor release in the rat utricle during a restricted period of devel - Chabbert, Mechaly, et al....
Voltage-gated Na + channels in chemoreceptor afferent neurons—Potential roles and changes with development ☆Carotid bodyNa+ channel... Donnelly,F David - 《Respiratory Physiology & Neurobiology》 被引量: 3发表: 2013年 Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing. PURPO...
电压门控钠通道SCN5A/Nav1.5在卵巢癌中的表达及意义 目的:电压门控钠通道(voltage-gated sodium channels,VGSCs)与多种恶性肿瘤的转移过程密切相关。本研究探索VGSCs亚型SCN5A/Nav1.5在人卵巢癌中功能性表达的意义及其对... 高瑞,沈怡,徐舒翔,... - 《肿瘤》 被引量: 0发表: 2009年 加载更多来源...
Voltage-gated sodium channels (NaVs) and calcium channels (CaVs) are involved in electrical signaling, contraction, secretion, synaptic transmission, and other physiological processes activated in response to depolarization. Despite their physiological importance, the structures of these closely related prote...
Voltage-gated Na(+) channel (Na(v)) 1.8 contributes to the majority of the Na(+) current that underlies the depolarizing phase of action potentials. Na(v)1.8 is mainly distributed intracellularly and its current amplitude can be enhanced by the beta3 subunit. However, little is known about...
Voltage-gated Naϩ channel activity and connexin expres- sion in Cx43-deficient cardiac myocytes. J Cardiovasc Electrophysiol 10: 1390-1401, 1999.Johnson CM, Green KG, Kanter EM et al. Voltage-gated Na1 channel activity and connexin expression in Cx43-deficient cardiac myocytes. J Cardiovasc ...
Voltage‐Gated Na+ Channel Activity and Connexin Expression in C×43‐Deficient Cardiac Myocytes Kanter EM, Bou-Abboud E, Saffitz JE, Yamada KA (1999) Voltage-gated Na+ channel activity and connexin expression in Cx43-deficient cardiac myocytes. ... MJMD Carolyn,KG Green,EM Kanter,... - ...