In vivo models for experimental thrombolysisCELL CYCLEERYTHROPOIESISERYTHROPOIETINDIFFERENTIATIONThe signal transduction pathways of urokinase (u-PA) in the human epidermoid carcinoma cell line, A431, were studied using the inducers epidermal growth factor (EGF) and 12-tetradecanoyl phorbol acetate (TPA)....
To provide a vascularized and functional in vivo model of brain organoids, we established a method for transplanting human brain organoids into the adult mouse brain. Organoid grafts showed progressive neuronal differentiation and maturation, gliogenesis, integration of microglia, and growth of axons ...
Objectives:To investigate variousin vitroandin vivomodels of the up- and down-stream signaling from neuron to astrocytes that regulate GLT1 expression. Methods:We first developed a novel neuron astrocyte co-culture system by using a microfluidic platform that only allows axons to approximate and/or...
This chapter gives an overview of the main types of in vivo models developed for the studies of bone metastases and cancer-induced bone disease in breast and prostate cancer, as well as in multiple myeloma, and gives examples of the information generated by some of the key published studies....
With over 300 mouse strains in our AAALAC-accredited animal facility, these in vivo models can help you move projects from target to IND application.
in both in vitro and in vivo models. In vitro, 100 nM AZ’6421, a concentration that causes maximal ERα degradation, failed to induce PR expression in the Ishikawa endometrial cell line (Fig.8a) suggesting that this molecule was a complete antagonist. A similar result was also observed ...
These traditional in vitro models have provided a wealth of information about neural cell types; examples include spontaneous network formation, cell attachment sites for adhesion and migration, axonal guidance mechanisms, molecules (soluble and insoluble) in synaptic targeting, and the resting membrane ...
Neuromics Models include Human Blood-Brain Barrier (BBB) and Human Umbilical Vein Endothelial Cells. The models are used to study the penetration rates of pathogens, compounds, proteins, and molecules through the microvascular endothelial cells barrier.
Parameterization of such models is a prerequisite step prior integration into clinical platforms. In this work, we first evaluated the errors associated with the registration process between contact EP data and MRI-based models, using in vivo CARTO maps recorded in three swine hearts (two healthy ...
Calcific Aortic Valve Disease (CAVD) is prevalent among the elderly as the most common valvular heart disease. Currently, no pharmaceutical interventions can effectively reverse or prevent CAVD, making valve replacement the primary therapeutic recourse.