Introducing in vivo pancreatic cancer models for the study of new therapeutic regimensSychra, T.Vaclavikova, R.Szabo, A.Spalenkova, A.Seborova, K.Balatka, S.Tesarova, T.Koci, K.Gurlich, R.Soucek, P.Surgical Review / Rozhledy v Chirurgii...
In vitro and ex vivo models include standard, genetically modified and patient-derived cell lines, spheroid and organoid culture models, scaffold and hydrogel cultures, and tissue slice models. In vivo models — including tumour xenografts, patient-derived xenografts and circulating tumour cell eXplant ...
The immune system can eliminate tumors, but checkpoints enable immune escape. Here, we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens across cancer models treated with immune checkpoint blockade (ICB). We identify immune eva
Understand your drug candidates’ potential pharmacological profile using a suite of validated in vivo models. Partner with us to select the most appropriate platform, study design, and screening method tailored to each of your individual drug candidates and research question. Each of our models are...
The preoperative (neoadjuvant) setting of breast cancer treatment is an optimal in vivo model by which to allow the characterization of biomarker expression pattern with the tumor remaining in situ throughout treatment as an in vivo measure of response to particular therapy. Elucidating surrogate ...
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Thus, Pin1 is essential for tumorigenesis and is an attractive anticancer target. Our ex vivo assay can be used to study early events of breast cancer development in genetically predisposed mice. 展开 关键词: Pin1 protein phosphorylation three-dimensional culture transgenic mice tumorigenesis ...
One common theme that emerges from these models is the importance of chronic cytokine-induced growth, survival, or inflammatory signals as a background leading to malignant transformation. Ultimately, better understanding of the cellular and molecular events that lead to the development of cancer will...
Nevertheless, additional studies on immunocompetent syngeneic mouse models could yield information about the role of AdVs as a delivery tool in cancer therapy. In the present study, we used adenoviral-based in vivo delivery of the CRISPR/Cas9 components as a proof-of-concept; however, we ...
Mouse models of human cancer have provided important insights into the genetic and molecular basis of human cancer and have been used to identify promising new treatment options for human patients. Genetically engineered mouse models (GEMMS) have been used to identify and characterize the basis of ...