The liver is also the major site of biotransformation and elimination, and is often a target organ for toxicity. In mammals , the liver has by far the greatest capacity to regenerate after injury of any organ.Vitro Methods in Pharmaceutical Research...
Hepatotoxicity: From Genomics to In Vivo and In Vitro Modelsdoi:10.1080/15563650902907921BryanBallantyneCharlestonWestVirginiaUSAInformahealthcareClinical Toxicology
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It was also reported that 3D bioprinted models were considered superior to simpler 3D in vitro models such as spheroid cultures [24]. As a result, multiple bioprinted liver and cancer cell-laden models were developed for predicting hepatotoxicity and chemotherapeutic responses [223,250,255,259...
et al. OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. Blood 108, 697–704 (2006). Article CAS PubMed Google Scholar White, D. L. et al. ...
To examine whether such heat treatment facilitates the hepatic metabolic activities, we also treated generally used hepatocytes (i.e., PHH, differentiated HepaRG, and HepG2 cells). Because PHH and differentiated HepaRG cells would lose their functions in in vitro cell culture, these cells were...
In vivo and in vitro hepatotoxicity and glutathione interactions of N-methyldithiocarbamate, N,N-dimethyldithiocarbamate and hydrogen sulfide anion in the ... Valentine WM (2002) In vivo and in vitro hepatotoxicity and glutathione interactions of N-methyldithiocarbamate and N, N dimethyldithiocarbama...
摘要: The hepatotoxicity of acetaminophen (APAP) seems to be linked to several biochemical perturbations such as glutathione depletion, oxidative stress, Ca 2+ homeostasis disturbances and/or changes in energy metabolism.DOI: 10.1007/978-3-642-79451-3_18 被引量: 50 ...
Rat hepatocytes, or a sandwich culture of rat and human hepatocytes, have been the most commonly used models for studying CPZ toxicity in vitro. However, to better predict outcomes in pre-clinical trials where cholestasis may be an unwanted consequence, a human in vitro model, based on human ...
with no toxicity. Studies carried out in mice have confirmed better efficiency, spleen infections being fully eliminated. Liposomes and immunoliposomes do not have cardio- or hepatotoxicity[154]. fMLP-liposomes direct primaquine to macrophagesin vitro.In hamsters, they show higher efficacy in removing...