The advancement of the invitro models for consistent, rapid, and cost-effective toxicity testing is of major importance. These invitro model systems used in toxicity testing have diverse advantages together with the decrease in the number of animals, the reduced price of animal maintenance, as ...
In vitromodel systemsIn vivomodel systemsFunctional enrichment analysisLiterature co-occurrence analysisHighlights ? We compared the effects of 33 compounKaterina Takova a bJean-Fred Fontaine a bRalf Mrowka cMiguel A. Andrade-Navarro a bMethods...
In the rat cells, CuO NPs had greater cytotoxicity. The rat cells were also more sensitive to CuO NPs than the human cells. Concentrations of H2O2 and glutathione increased and decreased, respectively, in IEC-6 cells after a 4-h exposure to CuO NPs, suggesting the formation of reactive ...
Considering the importance of the experimental models of DR, the key characteristics of various in vitro, in vivo, and ex vivo models commonly used in DR research are reviewed and summarised in this work. The benefits and limitations of these models are also discussed to understand their context...
Materials and methods Cell lines and cell treatments Human astrocyte 1321N1 cells and rat neuron PC12 cells were purchased from the European Collection of Authenticated Cell Cultures (ECACC, Porton Down, UK). 1321N1 cells were cultured in Dulbecco’s modified Eagle’s Medium (DMEM) (Gibco; Invi...
Ma Y (2009) In vitro models for nanotoxicity testing. In: Sahu S, Casciano D (eds) Nanotoxicity from in vivo and in vitro models to health risks. Wiley, United Kingdom, p 365Ma, Y In vitro models for nanotoxicity testing. In: Sahu, S, Casciano, D eds. (2009) Nanotoxicity from...
Altogether, these results uncover VCN-01 as a new promising alternative for the treatment of these aggressive malignancies. Materials and Methods Cell lines and culture conditions PFSK-1 (ATCC, Manassas, VA, USA; CRL-2060TM) was maintained in RPMI-1640 (Gibco, Life Technologies, NY, USA). ...
Methods Alzheimer's disease models comprising ICR mice and PC12 cells were established using Aβ25–35. The Morris water maze test was used to assess mouse behavior. Nissl staining revealed morphological changes in the mouse hippocampal neurons. To elucidate the mechanism of action of AST, ICR ...
2. Methods 2.1. Human serum samples Serum samples were obtained from 20 healthy male donors (10 smokers and 10 non-smokers), provided by Asterand (Detroit, MI, USA). Inclusion and exclusion criteria are listed in the Supplementary Information Appendix 1. The study was performed in accordance ...
There is, however, no record of the anti-inflammatory or analgesic activity in literature; hence, the aim of this work is to investigate the anti-inflammatory and analgesic properties of the plant with a view to validating its ethno-medicinal use. Materials and methods Plant collection and ...