Hepatotoxicity assayMicrofluidic devicePrimary human hepatocyteHepatocytes have been used for in vitro hepatotoxicity assays because of their ability to sustain intact liver-specific functions. Here, we demonstrate a hepatotoxicity assay system using primary human hepatocytes trapped in microholes of a ...
Hepatotoxicity: From Genomics to In Vivo and In Vitro Modelsdoi:10.1080/15563650902907921BryanBallantyneCharlestonWestVirginiaUSAInformahealthcareClinical Toxicology
As a result, multiple bioprinted liver and cancer cell-laden models were developed for predicting hepatotoxicity and chemotherapeutic responses [223,250,255,259–261]. Other bioprinted cell-laden models used for in vitro drug testing included the neural and uterine cell-laden models [262,263]...
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In vitro assessment using the Alamar blue assay demonstrated a significant reduction (p < 0.05) in percentage of cell growth in a time-dependent manner in the groups treated with PG, PG-LHRH, PTX, and PTX-LHRH. Subcutaneous triple-negative xenograft breast tumors were then induced in ...
Because PHH and differentiated HepaRG cells would lose their functions in in vitro cell culture, these cells were treated for 24 h. Interestingly, the CYP3A activities of PHH and HepaRG were significantly decreased after heat treatment at 39 °C for 24 h (p < 0.01, n = 3, ...
S Azri,AJ Gandolfi,K Brendel - 《Vitro Toxicology》 被引量: 55发表: 1990年 Precision-Cut Rat Liver Slices in Dynamic Organ Culture for Structure-Toxicity Studies We describe a novel in vitro mammalian liver system, which simplifies both metabolism and hepatotoxicity studies in a multitude of spe...
How- ever, if it is taken into consideration that 3-BrPA exhib- ited a higher IC50 value (87.84 μM) than ABZ (38.7 μM) in the in vitro cytotoxicity assay, and at the effective dose against E. granulosus protoscoleces and E. multilocularis metacestodes, 3-BrPA did ...
Whilst the precise nature of DHODH inhibitor associated hepatotoxicity has yet to be resolved, previous studies using hepatic cell lines have implicated mitochondrial dysfunction as a putative mechanism by which leflunomide and teriflunomide elicit their adverse effects in vitro(Xuan et al., 2018;Ren et...
Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals Nucleic Acids Res, 35 (2007), pp. 687-700 CrossrefView in ScopusGoogle Scholar 35 S Obad, CO dos Santos, A Petri, M Heidenblad, O Broom, C Ruse, et al. Silencing of mic...