In vitro metabolism study of buprenorphine: evidence for new metabolic pathways. Drug Metab Dispos. 2005;33(5):689–95.Picard, N, Cresteil, T, Djebli, N, Marquet, P (2005) In vitro metabolism study of buprenorphine: evidence for new metabolic pathways. Drug Metab Dispos...
IQVIA Laboratories offers a suite of in vitro assays to support drug-drug interaction testing, including cytochrome P450 (CYP) enzyme inhibition (IC50), time-dependent CYP inhibition, induction of CYP enzymes, and CYP reaction phenotyping. All in vitro metabolism assay results are presented in fully...
This study was performed in order to evaluate in vitro models (human liver microsomes and S9 fraction) for the prediction of the metabolism of peptidic doping agents and to compare them with the established models. The peptides that were investigated include desmopressin, TB-500, GHRP-2, GHRP-...
To understand the cause of the biological effects of xenobiotic metabolism in mammals, investigators have traditionally performed animal experiments by comparing the results of biochemical methods, such as measurement of enzyme activity analysis of the metabolites produced, with the observed toxicological eff...
The addition of methionine, folinic acid, methyl-B12, thymidine, or dimethylglycine to the cultured trisomy 21 lymphoblastoid cells improved the metabolic profile in vitro. The increased activity of CBS in children with DS significantly alters homocysteine metabolism such that the folate-dependent ...
In vitro studies in the context of pro- or anti-inflammatory activation highlight the metabolic plasticity of macrophages, which can completely rewire aspects of their cellular metabolism—bioenergetics, nutrient usage, generation of metabolites/cellular building blocks, etc.—depending on the task at ...
In Vitro Methods to Study Intestinal Drug Metabolism Although the liver has long been thought to play the major role in drug metabolism, also the metabolic capacity of the intestine is more and more recognize... EVD Kerkhof,ID Graaf,G Groothuis - 《Current Drug Metabolism》 被引量: 328发表...
The deleterious effects of abnormal iron accumulations on MS metabolism have been recently reviewed [15], [20], [22]. The origin of the elevated iron deposits in MS is unknown, but they are not necessarily simply a consequence of release from glial intracellular ferritin stores [23] or ...
Metabolism in vitro by preparations of liver 1. The isolation and partial purification of 11beta-hydroxy steroid dehydrogenase from rat and guinea-pig liver microsomes has been achieved by conventional methods. 2. The efficiency of different 11-oxygenated steroids as substrates has... IE Bush,SA ...
into each well to solubilise the formazan salt crystals produced by the metabolism of live cells and the microplate was incubated at room temperature (RT) for 30 min. Finally, absorbance was measured at 570 nm using an iMark microplate reader (Biorad). Cell vitality was reported as the ...