During the process of anticancer drug discovery and preclinical testing research, a more physiological in vitro cancer model can provide more reliable data. Due to the three-dimensional (3D) nature of tumor structure, significant discrepancy in drug efficiency was found when compared between in vivo...
Cancer and Metastasis Reviews, 2018, 37: 719-731. [2] RODRIGUES, João; SARMENTO, Bruno; PEREIRA, Catarina Leite. Osteosarcoma tumor microenvironment: the key for the successful development of biologically relevant 3D in vitro models. In vitro models, 2022, 1.1: 5-27. ♥ 喜欢我们的内容,...
Cancer research has predominantly focused on two-dimensional (2D) cultured human cell lines during the past decades. Although these models have (i) improved our understanding of cellular signalling pathways, (ii) helped us identify potential drug targets and (iii) guided the design of candidate dru...
Androgen deprivation therapy has a central role in the treatment of advanced prostate cancer, often causing initial tumour remission before increasing independence from signal transduction mechanisms of the androgen receptor and then eventual disease progression. Novel treatment approaches are urgently needed,...
Cancer cells, stem cells and cancer stem cells have for a long time played a significant role in the biomedical sciences. Though cancer therapy is more effective than it was a few years ago, the truth is that still none of the current non-surgical treatments can cure cancer effectively. The...
One avenue, not often explored within 3D in vitro tumour models, is the effect of the tumour stroma on cancer growth and invasion. ECM density and composition are factors that are often overlooked in cancer research but have increasingly been implicated as significant factors involved in cancer ...
Thus, although new models are being developed, the complexity of the tumor stroma in vitro has not yet been achieved. Nevertheless, recent advances in 3D cancer models have the potential to (i) improve drug discovery, (ii) be used as platforms for drug testing, and (iii) enable the ...
In vitro models of thyroid cancer. 来自 NCBI 喜欢 0 阅读量: 28 作者: D Wynford-Thomas 摘要: The well defined multiple steps and alternative pathways of thyroid follicular cell in vivo provide a theoretically ideal basis for modelling the process of epithelial in vitro. Much progress has ...
As in vitro models for cancer research, traditional two-dimensional (2D) cell line cultures and mouse models are frequently utilized for preclinical studies. Despite their unique contributions to the development of cancer science, they are also fraught with some challenges. For example, 2D cell line...
cancer. More sophisticated models also have been proposed, such as NSCLC based tumor spheroid45,46,47, microfluidic chip-based 3D co-cultures48,49,50,ex vivo3D lung cancer models based on a decellularized matrix51,52, patient derived xenograft models53, and precision-cut lung tumor biopsies54,...