来自波尔图大学的Bruno Sarmento和Catarina Leite Pereira教授团队,于2022年1月在《In vitro models》杂志上以“Osteosarcoma tumor microenvironment: the key for the successful development of biologically relevant 3D in vitro models[2]”为题发表文章。本综述简要概述了骨稳态,然后详细描述了骨微环境在肿瘤发展过程...
In vitro models, in vivo models, and pharmacokinetics: what can we learn from in vitro models? Clin Infect Dis. 2001; 33 Suppl 3:S214-20. doi: 10.1086/321850 PMID: 11524721.Alasdair MacGowan, Chris Rogers, and Karen Bowker, In Vitro Models, In Vivo Models, and Pharmacokinetics: What ...
Representative examples are shown from three independent experiments. Scale bars, 100 μm. Extended Data Fig. 2 Effect of Chiron pre-treatment on human ES cells. a, Gene expression in adherent RUES2-GLR cells after 24 h of Chiron pre-treatment (ChiPT) compared to cells that were not pre-...
Based on the influences of tissue geometry observed in these examples, it is important to develop in vitro models with improved physiologically relevant tissue structure in order to complement and overcome the limitations inherent in current in vivo and in vitro models and improve researchers’ ...
and poor availability of relevant in vitro and in vivo models to study the tumor progression and the metastatic cascade, the pathophysiology of OS is still poorly understood and the translation of novel drugs into the market has become stagnant. Due to the importance of the tumor microenvironment...
in both in vitro and in vivo models. In vitro, 100 nM AZ’6421, a concentration that causes maximal ERα degradation, failed to induce PR expression in the Ishikawa endometrial cell line (Fig.8a) suggesting that this molecule was a complete antagonist. A similar result was also observed ...
the predictive power of currently available in vitro models is still poor. This seems to be one of the main reasons for the continuous drop in the number of new drugs appearing yearly, dumping billion-dollar investments15,16. For example, despite structural three-dimensionality is one of the ...
PREDECT was an IMI-funded partnership between academic, SME and pharmaceutical company partners with the goal to develop and characterise complex in vitro models for breast, prostate and lung cancers. MJ Hinner,RSB Aiba,C Schlosser,... - 《Cancer Immunology Research》 被引量: 11发表: 2016年 ...
Fig. 4: Classification of one-channel EAP (extracellular action potential) features of single-cell models and correspondence to in vitro data modalities. a,bBio-realistic single-cell models (one aspiny, AP, panel (a); one aspiny, SP, panel (b)) activated via synaptic activity along their re...
Fig. 2.2.Scheme of in vitro digestion process. There are several in vitro systems with different technological complexities and biological importance, from static mono-compartmental to dynamic multicompartmental models. Some examples of assays performed with in vitro methods for bioaccessibility determination...