The recent identification of cancer stem cells (CSCs) in multiple human cancers provides a new inroad to understanding tumorigenesis at the cellular level. CSCs are defined by their characteristics of self-renewal, multipotentiality, and tumor initiation upon transplantation. By testing for these defin...
According to the theory, a minority population of cancer cells is capable of self-renewal and generation of differentiated progeny, termed cancer stem cells (CSCs). Understanding the properties and characteristics of CSCs is key to future study on cancer research, such as the isolation and ...
Cancer stem cell: target for anti-cancer therapy Cancer has long been viewed as a heterogeneous population of cells. While the great majority of cells that make up tumors are destined to differentiate, al... C Tang,BT Ang,S Pervaiz - 《Faseb Journal Official Publication of the Federation of...
Study of these cancer-driving cells within tumours has been slow because it has been hard to identify them unequivocally, separate them out and study them in the lab. Previously, identifying cancer stem cells has relied on working with cancer biopsies from human patients. Scientists have tried to...
Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives Colorectal cancer remains one of the most common and lethal malignancies worldwide despite the use of various therapeutic strategies.A better understanding of the mechanisms responsible for tumor initiation an...
Stem cell in cancer: Do they matter?Stem cell in cancer: Do they matter? - Experimental Hematologydoi:10.1016/j.exphem.2015.06.028DickJohn E.Elsevier Inc.Experimental Hematology
Malignant stem cells in the gut secrete factors that promote the differentiation of neighbouring stem cells, thereby aiding the replacement of normal stem cells by those with cancer-promoting mutations. By Shi Biao Chia & James DeGregori Twitter Facebook Email Decades of research have revealed how ...
human breast cancer primary cells,the proportion of cancer stem cells in MCF-7 and MDA-MB-231S cells was higher(P 0.01).Conclusion Compared with human breast cancer primary cells,there are more breast cancer stem cells in the human breast cancer cell line and the phenotype has been changed....
The study was published today inCell. "We found a population, unbeknownst to anyone, that seems to be a 'kingpin' of a stem cell ecosystem that is required to maintain and grow all the other cells," said Mick Bhatia, director of the Stem Cell and Cancer Research Institute and professor ...