Cancer is not a cell-autonomous disease, but involves disruption of the complex system of controls exerted by the local microenvironment, as well as hormonal or immune-system components produced by the whole organism. Cancer, like any other tissue that is capable of regeneration or progressive grow...
But the cell of origin and the type of cells that propagate the tumor after its initiation are still unknown. The concept of Cancer Stem Cells (CSC) was first developed for hematologic malignancies and later applied to solid neoplasias. This model suggests that tumors are hierarchically organized...
Cancer stem cells are rare immortal cells within a tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, and can therefore form tumours. Such cells have been found in various types of human tumours and might be attractive targets for cancer...
Introduction The cancer stem cell model for tumor progression is the first model of its type to suggest that only one subpopulation of cancer cells is capable of proliferating indefinitely. These cells resemble normal stem cells in their capacity for self-renewal and multi-potential differentiation, ...
In subject area: Agricultural and Biological Sciences Cancer stem cells (CSCs) could be defined as “a cell within a tumor that posses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor.” ...
Stem Cell:细胞静止与癌症的关系 编辑推荐: 生物通报道:来自美国纽约斯隆/凯德琳癌症纪念研究中心(Memorial Sloan-Kettering Cancer Center,简称MSKCC,生物通注)的研究人员发现造血干细胞中肿瘤抑制因子p53表达水平会增加,当对一个细胞进行化疗或者放射性治疗的时候,如果这个细胞缺乏p53或者一个称为MEF的基因,那么细胞不仅...
2024年4月24日,来自美国希望之城国家医疗中心血液学与造血细胞移植科的Jianhua Yu与Michael A. Caligiuri共同在Cell Stem Cell期刊发表题为Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer(人类抗PS...
2022年8月4日,来自牛津大学人类遗传学惠康中心的Simon J Leedham团队在Cell Stem Cell上发表题为Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia的文章,作者开发了一种适用的、易于使用的转录分子工具...
5. A.Kreso, J. E. Dick, Evolution of the cancer stem cell model. Cell Stem Cell 14, 275-291 (2014).6. C.L. Chaffer, R. A. Weinberg, A perspective on cancer cell metastasis. Science 331, 1559-1564 (2011).7. A.Casali, E. Batlle, Intestinal stem cells in mammals and Drosophila...
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.