But the cell of origin and the type of cells that propagate the tumor after its initiation are still unknown. The concept of Cancer Stem Cells (CSC) was first developed for hematologic malignancies and later applied to solid neoplasias. This model suggests that tumors are hierarchically organized...
Introduction The cancer stem cell model for tumor progression is the first model of its type to suggest that only one subpopulation of cancer cells is capable of proliferating indefinitely. These cells resemble normal stem cells in their capacity for self-renewal and multi-potential differentiation, ...
In subject area: Engineering Cancer stem cells (CSCs) are rare population of cells that are bestowed with the capability to generate itself bypassing the cell cycle checkpoint mechanisms and are implicated in tumor initiation, metastasis, and relapse or drug resistance. ...
Cancer is not a cell-autonomous disease, but involves disruption of the complex system of controls exerted by the local microenvironment, as well as hormonal or immune-system components produced by the whole organism. Cancer, like any other tissue that is capable of regeneration or progressive grow...
Cancer stem cells are rare immortal cells within a tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, and can therefore form tumours. Such cells have been found in various types of human tumours and might be attractive targets for cancer...
Stem cells have been widely studied in the fields of cancer biology. Yet, many fundamental questions regarding the specific roles of stem cell in cancer progression and therapy remain elusive, impeding the effective clinical translation of stem cell research. On the one hand, cancer stem cells (...
Stem Cell:细胞静止与癌症的关系 编辑推荐: 生物通报道:来自美国纽约斯隆/凯德琳癌症纪念研究中心(Memorial Sloan-Kettering Cancer Center,简称MSKCC,生物通注)的研究人员发现造血干细胞中肿瘤抑制因子p53表达水平会增加,当对一个细胞进行化疗或者放射性治疗的时候,如果这个细胞缺乏p53或者一个称为MEF的基因,那么细胞不仅...
编译自:Stem cell research aids understanding of cancer doi:10.1002/stem.1167 PMC: PMID: The GCTM-5 Epitope Associated with the Mucin-Like Glycoprotein FCGBP Marks Progenitor Cells
Huntly and Gilliland6 outlined the evolution of cancer stem cell (CSC) research from 1855. The leukemis stem cells (LSCs) were the first to be described as CSCs in human acute myeloid leukemia (AML)7. Bonnet and Dick8 demonstrated that a subpopulation of CD34+ CD38−AML cells possessed ...