But the cell of origin and the type of cells that propagate the tumor after its initiation are still unknown. The concept of Cancer Stem Cells (CSC) was first developed for hematologic malignancies and later applied to solid neoplasias. This model suggests that tumors are hierarchically organized...
Introduction The cancer stem cell model for tumor progression is the first model of its type to suggest that only one subpopulation of cancer cells is capable of proliferating indefinitely. These cells resemble normal stem cells in their capacity for self-renewal and multi-potential differentiation, ...
Cancer is not a cell-autonomous disease, but involves disruption of the complex system of controls exerted by the local microenvironment, as well as hormonal or immune-system components produced by the whole organism. Cancer, like any other tissue that is capable of regeneration or progressive grow...
In subject area: Engineering Cancer stem cells (CSCs) are rare population of cells that are bestowed with the capability to generate itself bypassing the cell cycle checkpoint mechanisms and are implicated in tumor initiation, metastasis, and relapse or drug resistance. ...
Stem Cell:细胞静止与癌症的关系 编辑推荐: 生物通报道:来自美国纽约斯隆/凯德琳癌症纪念研究中心(Memorial Sloan-Kettering Cancer Center,简称MSKCC,生物通注)的研究人员发现造血干细胞中肿瘤抑制因子p53表达水平会增加,当对一个细胞进行化疗或者放射性治疗的时候,如果这个细胞缺乏p53或者一个称为MEF的基因,那么细胞不仅...
Cancer stem cells are rare immortal cells within a tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, and can therefore form tumours. Such cells have been found in various types of human tumours and might be attractive targets for cancer...
They found that a region around SOX2 was frequently replicated in both diseases. SOX2 expression is necessary for the growth of lung and oesophageal squamous-cell cancer lines. Overactivating SOX2 also turned normal cells cancerous with help from a couple of other genes. Rights and permissions ...
Stem cells, cancer, and cancer stem cells Nature, 414 (2001), pp. 105-111 Google Scholar 33 H. Kitamura, K. Okudela, T. Yazawa, H. Sato, H. Shimoyamada Cancer stem cell: implications in cancer biology and therapy with special reference to lung cancer Lung Cancer, 66 (2009), pp. ...
Notch-1 induces Epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells (Retraction of Vol 307, Pg 26, 2011) Pancreatic cancer (PC) is one of the most lethal malignant tumors, which often result from diagnoses of advanced stages and ineffective therapi...