One of these genes showed high similarity to a periplasmic protein of unknown function and its isogenic mutant showed decreased toxicity compared to the C. jejuni 81116 wild type. This gene contains a Gram-negative bacterial RTX toxin-activating protein C signature, which suggests it may play a ...
Using a repetitive sequence of tandemly arrayed pentanucleotides in the human H19 3′-flanking region, we isolated a phage clone (λ PEN11) which localized to chromosome 11p15.5. The λ PEN11 phage encodes a 2.3-kb cDNA consisting of seven exons at least. The gene was mainly expressed in...
W. 2001 . Isolation of an early neural maker gene abundantly expressed in the nervous system of the ascidian, Halocynthia roretzi . Dev. Genes Evol. 211 , 49 – 53 .Yagi K, Makabe KW (2001) Isolation of an early neural maker gene abundantly expressed in the nervous system of the ...
The interplay between chromatin, transcription factors and genes generates complex regulatory circuits that can be represented as gene regulatory networks (GRNs). The study of GRNs is useful to understand how cellular identity is established, maintained and disrupted in disease. GRNs can be inferred...
In the present study, we isolated and characterized a MYB transcription factor gene (MdMYBA) from apple skin. Characterization of MdMYBA demonstrated that (i) MdMYBA expression was specifically regulated depending on the tissue and cultivar/species; (ii) its expression level was much higher in...
In a previous study of a mouse model of targeted disruption of the UG gene, the same phenotype had not been observed (Stripp et al. 1996). We previously had examined the hypothesis that a genetic defect in the genes for Fn or UG was responsible for GFND. By use of haplotype analysis ...
Targeting ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal overload of lipid peroxides, in cancer therapy is impeded by our limited understanding of the intersection of tumour’s metabolic feature and ferroptosis vulner
Reproductive isolation (RI) is a universal biological phenomenon that restricts gene flow between populations and thus serves as both an indicator of speciation and a mechanism for maintaining species identity. Multiple pre-fertilization (pre-zygotic) and post-fertilization (post-zygotic) barriers, such...
Mosquitoes have profoundly affected human history and continue to threaten human health through the transmission of a diverse array of pathogens. The phylogeny of mosquitoes has remained poorly characterized due to difficulty in taxonomic sampling and li
Artificial metalloenzymes (ArMs) integrated within whole cells have emerged as promising catalysts; however, their sensitivity to metal centers remains a systematic challenge, resulting in diminished activity and turnover. Here we address this issue by i