In situ Hi-C是改良的高通量染色质捕获技术(High-throughput chromosome conformation capture,Hi-C),通过保证实验前期细胞核的完整性,相比较传统Hi-C而言能有效减少实验背景噪声,提高交互矩阵分辨率。Insitu Hi-C最初是针对人类、小鼠等动物细胞研究开发的技术,但由于植物细胞存在细胞壁从而难以获得完整的细胞核,使其...
. To characterize how chromatin structure is globally re-organized during skeletal muscle progenitor specification and differentiation, we generated chromosomal conformation maps using in situ Hi-C and pCHi-C and performed chromatin immunoprecipitation (ChIP)-seq to detect CTCF and cohesin (Smc3) ...
The development of facile and efficient polymerizations toward functional polymers with unique structures and attractive properties is of great academic and industrial significance. Here we develop a straightforward C–H-activated polyspiroannulation rou
364 Online In-Situ Interleaved Evaluation of Real-Time Push Notification Systems Adam Roegiest; Luchen Tan; Jimmy Lin SIGIR 2017 6 365 Word-Entity Duet Representations for Document Ranking Chenyan Xiong; James P. Callan; Tie-Yan Liu SIGIR 2017 6 366 Neural Networks for Information Retrieval Tom...
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“Identification of programmed cell death in situ Via, specific labelling of nuclear DNA fragmentation” Jl Cell Biol 1992; 119:493–501. Article CAS Google Scholar Gazzeri S, Brambilla E, Caron de Fromentel C, Gouyer V, Moro D, Perron P, Berger F and Brambilla C. “p53 genetic ...
[30]. The SNMP1 subfamily is coexpressed with pheromone receptors, and in situ hybridization indicated that it is associated with pheromone-sensitive neurons [31]. SNMP1 has been confirmed to participate in pheromone signal transduction. The SNMP2 subfamily was first identified fromManduca sextaand...
[5] C.J. Spencer, C.L. Kirkland, N.M.W. Roberts, N.J. Evans, J. Liebmann. Strategies towards robust interpretations of in situ zircon Lu–Hf isotope analyses[J]. Geoscience Frontiers, 2020, (3): 843-853. DOI: 10.1016/j.gsf.2019.09.004 [6] João Marinho Milhomem Neto, Je...
For each germ cell fraction, we performed in situ Hi-C3,16 to generate genome-wide Hi-C maps for primary spermatocytes and round spermatids. The Rb somatic profile was derived from a wild-caught Rb male primary fibroblast cell line belonging to the BRbS. Germ cell and somatic data for ...
Helicobacter pylori infection is implicated in the aetiology of many diseases. Despite numerous studies, a painless, fast and direct method for the in situ detection of H. pylori remains a challenge, mainly due to the strong acidic/enzymatic environment