Phenotypic sex in salmonids is determined primarily by a genetic male heterogametic system; yet, sex reversal can be accomplished via hormonal treatment. In Tasmanian Atlantic salmon aquaculture, to overcome problems associated with early sexual maturati
Each mammalian autosomal gene is represented by two alleles in diploid cells. To our knowledge, no insights have been made in regard to allele-specific regulatory mechanisms of autosomes. Here we use allele-specific single cell transcriptomic analysis to
and CRISPR-Cas systems are capable of generating double-strand breaks (DSBs) at precise locations within the genome. Moving on to the second part (b), the introduction of DNA sequences or mutations into the DNA can be
We observe one CNV that differs from the reference in all samples, indicating that it is a singleton in the reference (chromosome 15, 57.86 to 57.88 Mb). This corresponds well with the number of singletons found in other samples, suggesting these numbers are accurate. However, this contrasts...
There are, however, no indications for a similar expression pattern, neither in fishes nor in mice, and we cannot observe a brain phenotype in our mouse Eya3 mutants. To our knowledge, this Eya3-deficient mutant is the first mouse model for a mutation affecting Eya3 and therefore an ...
This can be explained by the use of different genetic markers[79]. The use of allozymes [77, 78] vs. SNPs (present study) may have contributed to the somewhat larger values of genetic differentiation observed in previous studies compared to the current study. Even though we observe an ...
We next explored the role of islet splicing variation in T1D. Despite the fact that T1D is an autoimmune disease, several observations indicate that a fraction of T1D risk alleles act through β-cells or exocrine pancreatic cells, rather than directly through immune cells [5,14,35]. Further...
On the other hand, pollen can also have serious negative effects. For example, many ornamental plants produce excessive amounts of pollen, including Populus, lily, and chrysanthemum, and exposure to high amounts of pollen can lead to an anaphylactic reaction in susceptible populations [4,5,6]....
Mining of the responding TFH T cell receptor repertoire revealed a strikingly immunodominant HLA-DPB1∗04-restricted response to S167–180 in individuals with this allele, which is among the most common HLA alleles in humans. Paired blood and lymph node specimens show that while circulating S-...
Nowadays, another possibility used is the combination of CE with fluorescence, which can be used to observe the separation process, and in this way monitor the operational conditions and the microbial dynamics in terms of cell aggregation and focusing effects [145,146,147]. The main advantage of...