Extension of the Haseman-Elston method to multiple alleles and multiple loci. Theory and practice for candidate genes. Ann. Hum. Genet. 61:263-274.Stoesz M R,Cohen J C,Mooser V,et a1.Extension of the Haseman--Elston method to multiple alleles and multiple loci: theory and practice for...
Both alleles act by allowing for optimal binding in their own HLA pocket, resulting in antigen presentation in the former, and enhancement of CD8 activity due to cross-stimulation of myelin-reactive T-cell receptor in the latter. The imbalance between genes induces susceptibility to getting sick ...