An example of multiple alleles is coat color in rabbits (Figure 1). Here, four alleles exist for the c gene. The wild-type version, C+C+, is expressed as brown fur. The chinchilla phenotype, cchcch, is expressed as black-tipped white fur. The Himalayan phenotype, chch, has black fur...
(null);S, dominant susceptible allele;s, recessive resistant allele.bX-ray crystal structure ofS. pyogenesCas9 (PDB ID: 6o0z, left) and diagram of dominant lethal gene product, dCas9-VPR.cInteraction of dCas9-VPR with resistant (top) or susceptible (bottom) alleles. Blue square represents...
A single genetic mutation in Sia biology could have become universal to humans simply as a result of such a random mutation drifting to fixation in a small effective population size [14]. However, it was subsequently found that at least 10 other genes involved in Sia biology have undergone hu...
Journal of Mathematical BiologyTURELLI, M. 1981. Temporally varying selection on multiple alleles: A diffusion analysis, J. Mafh. Biol. 13, 115-129.TURELLMI,., 1981 Temporally varying selection on multiple alleles: a diffusion analysis. J. Math. Biol. 13: 115-129....
These situations can be differentiated based on the presence or absence of a distinct intermediary stage, with mutations present on two out of three alleles (intermediate variant allele fraction 50%). The presence of an intermediary stage indicates that sufficient time has passed between the two ...
[122]. It is unclear if the larger number of CAG repeats in normal alleles ofATXN1andATXN2amongst Caucasians is a contributory factor [123]. These expansions seem to be more associated with MSA-C than MSA-P, but more data are still needed as cases have been reported in both groups [...
The mutant alleles used were: cdka;1-1, gcs1, kpl-2, mea-7, fis2-6, dme-1, drm1-2, drm2-2, cmt3-11t, met1-3, rdr2-1, nrpd1a-4, nrpd1b-11, and kyp-6. All plants were grown on soil at 22°C under continuous light. We also used wild-type plants carrying pLAT52:...
For instance,Helianthus bolanderisuffered a rapid reduction in its population size owing to genetic swamping by the common invasiveH. annuus[6]. Asymmetric introgression also occurs betweenIris fulvaandI. brevicauliswhere 72% of theI. brevicaulis-like plants have alleles introgressed fromI. fulva[...
alleles of the p53 gene [36], located ~35 kb from the distal end of the SHBG gene locus on chromosome 17p13.1 and, due to this extremely close linkage, we presumed that both SHBG alleles also remain intact. We initially intended to confirm prior reports of SHBG mRNA expression in these...
However, these findings could not be replicated in Asian populations [25,26,27] and this could, in part, be related to the differences in the frequency of the risk alleles in different populations since the prevalence of the rs11931074 “T” allele is considerably higher in Asian populations ...