SNPs are now widely used in genetic analysis and breeding. Large-scale genotyping at the whole-genome level is becoming increasingly important for understanding the genetic architecture of complex traits2. Sequencing technology improved greatly over the last four decades, with technical advances from ...
In this paper, we describe for the first time detailed expression patterns of genes that are related to SNPs that were determined by GWAS to be linked to ARHL. We find widespread expression of these genes in many cell types in the cochlea, indicating the susceptibility of a wide range of ...
Genome-wide association studies (GWASs) have successfully identified and characterized genetic variants associated with lipid traits1,2,3. To date, roughly 700 single-nucleotide polymorphisms (SNPs) are associated with various lipid traits3,4,5,6,7,8,9. These discoveries are now beginning to unra...
which were used in genetic diversity studies [46], and the variation among compiled contigs, potentially being derived from two parental nuclei in case of the dikaryotic material or the 4 different isolates used, revealed SNPs (Single Nucleotide Polymorphisms) which are being used to saturate a ...
Population genetics structure. (A–C) Principal component analysis of identified SNPs. (D) Linkage disequilibrium (LD) decay. (E) Genome-wide admixture analysis Full size image To further investigate the degree of selection of different goose breeds, we calculated LD values for each breed (Fig....
The availability of an expanded list of candidate effector genes, as opposed to lists of genes that are located in the vicinity of associated SNPs, allowed us to explore the hypothesis that a subset of genetic signals could influence T2D susceptibility by acting on specific cellular pathways in ...
In this study, the LD values among SNPs decreased with increasing physical distance, which is in accordance with studies on different livestock species [42, 45]. The relatively low levels of LD in the entire genome of cross-bred animals are probably the result of past admixture events between...
are more effective and safer for each individual. Additionally, SNPs can be used to understand the molecular mechanisms of sequence evolution. It has been found that throughout the given gene, the rate, type and site of nucleotide substitutions as well as the selection pressure on codons is ...
(PFC) neurons from PD patients and whose protein product is involved in mitochondrial biogenesis;SLC1A7, encoding a glutamate transporter;FXR2, whose protein product is involved in DNA damage response; andST5, SNPs of which are associated with PD progression, and whose protein product is ...
(Genetics of Glucose Regulation in Gestation, n = 573, and Hyperglycemia and Adverse Pregnancy Outcomes (HAPO), n = 4431) that genetic risk scores for elevated fasting glucose and insulin, reduced insulin secretion and sensitivity, and T2D, built using SNPs linked to glycemic traits in non-...