et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J. Exp. Med. 206, 1327–1337 (2009). CAS PubMed PubMed Central Google Scholar Pander, J. et al. Activation of tumor-promoting type 2 macrophages by ...
In acute-MS lesions, iNOS was localized in both monocytes/macrophages and reactive astrocytes. However, foamy (myelin-laden) macrophages and the majority ... EL Oleszak,E Zaczynska,M Bhattacharjee,... - 《Clinical & Diagnostic Laboratory Immunology》 被引量: 0发表: 1998年 McManus, C. et ...
Human inactivated PI3Kγ syndrome confirms the immunomodulatory roles of PI3Kγ and strengthens newly defined roles of this molecule in modulating inflammatory cytokine release in macrophages. Here, we review the functions of PI3Kγ in the immune system and discuss how our understanding of its ...
According to well-known molecular mechanisms underlying macrophage activation, TNFalpha is a gene product of MyD88-dependent pathway (common to both monocytes and macrophages) while IFNbeta is an autocrine product destined to launch MyD88-independent pathway specific for macrophages [2]. In the case...
Both MDSCs and tumor associated macrophages (TAMs) infiltrate human tumors, and the intra-tumoral density of both cell types correlating with poor survival [46, 47]. These data strongly support a scenario in which myeloid cell-derived immunosuppression, along with the recruitment of immunosuppressive...
both sexes displayed highARtranscription. In female lesions,ARand the microglial Iba1 staining were substantially colocalized suggesting thatARwas mostly up-regulated in microglia (and possibly infiltrated macrophages23,24) and at a much lower level in GFAP-expressing astrocytes and Olig2+...
three cell types, inside blood vessels (monocytes) or outside blood vessels (macrophages and mast cells) allow them to respond to dengue virus infection with the production of both intracellular and secretory factors which affect virus replication, vascular permeability and/or leukocyte extravasation. ...
At later stages, vascular cells such as VSMCs, ECs, monocytes and macrophages undergo senescence and release multiple cytokines as part of the SASP, which augment the preexisting inflammation. Senescence of endothelial cells Endothelial cell senescence and endothelial cell dysfunction [111] are ...
While not significant, the abundance of glial cells was anti-correlated with most inflammatory cells including neutrophils, inflammatory fibroblasts, M1 macrophages and inflammatory monocytes. We propose that the presence of Glia is associated with a preserved intestinal architecture, while inflammation may...
Monocytes and macrophages This article is cited by Yin-Yang: two sides of extracellular vesicles in inflammatory diseases Bin Zeng Ying Li Li Duan Journal of Nanobiotechnology(2024) Tissue-resident bacteria in metabolic diseases: emerging evidence and challenges ...