When direct contact between the peripheral blood cells and the ST2 cells was inhibited by a collagen-gel sheet, no TRAPase-positive cells were formed. These results indicate that osteoclasts are also derived from the mature monocytes and macrophages when a suitable microenvironment is provided by ...
Monocytes and macrophages have crucial and distinct roles in tissue homeostasis and immunity, but they also contribute to a broad spectrum of pathologies and are thus attractive therapeutic targets. Potential intervention strategies that aim to manipulate these cells will require an in-depth understanding...
Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system. Dendritic cells initiate and regulate the highly pathogen-specific adaptive immune responses and are central to the development of immunologic memory and...
Monocytes and macrophages are members of the reticuloendothelial system (RES), a multi-cellular system designed to clear particles within the circulation and tissues. Many nanoparticle strategies attempt to evade monocytes [2], [3]. However, with this barrier out of the way, monocyte delivery bec...
SARS-CoV-2 can cause acute respiratory distress and death in some patients1. Although severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers inflammation is not clear2. Monocytes and macrophages are sentinel cells that sense invasive infection to form inflammasomes that act...
Monocytes and macrophages: developmental pathways and tissue homeostasis.doi:10.1038/nri3671Monocytes and macrophages have crucial and distinct roles in tissue homeostasis and immunity, but they also contribute to a broad spectrum of pathologies and are thus attractive therapeutic targets. Potential ...
Monocytes are direct precursors of hematopoietic stem cell-derived macrophages. After their recruitment into the tumor tissue, they can differentiate into tumor-associated macrophages, a very heterogeneous cell population in terms of phenotype and pro-tumor function, supporting tumor initiation, local ...
aare the most potent effector cells, followed by[translate] ainfection with Cryptococcus neoformans, despite[translate] aIn contrast, DCs possess fungicidal activity[translate] ainfections with most fungal pathogens, but[translate] amacrophages and monocytes are permissive for[translate]...
They are able to exert specific roles in homeostasis and inflammation/immunity in vivo. Functional characterization of myeloid cells, including tissue resident macrophages, is in progress in both humans and rodents and will provide a better understanding of the pathophysiology of inflammatory diseases. ...
(2) immune cells are known to localize to lungs in a CXCR3-dependent manner10,11, and (3) the pro- duction of CXCR3 ligands in the lung is induced by introduction of circulating melanoma cells11, we hypothe- sized that CXCR3+ monocytes/macrophages may facilitate tumor engraftment in ...