More recently, the mechanisms of drug resistance of debilitating pathogens have also been found to be linked with the alterations in protein structure and function. In this regard, the superbug Mycobacterium tuberculosis and its repertoire of "intelligent" proteins help us to gain insights on many ...
Protein degradation is important because it: Releases amino acids. The amino acids released from the protein degradation help in the formation of new... Learn more about this topic: Quaternary Structure of Protein | Definition, Function & Examples ...
The coupling of structure-based approaches such as virtual screening and molecular docking with molecular dynamics and/or Monte Carlo simulation aids in reflecting the dynamics of proteins in nature into previously static docking studies, thus enhancing the accuracy of rationally designed ligands. This ...
Understanding the relationship between amino acid sequences and folding rate of proteins is a challenging task similar to protein folding problem. In this work, we have analyzed the relative importance of protein sequence and structure for predicting the protein folding rates in terms of amino acid ...
What does Protein Refolding in vitro Tell us about Protein Folding in the Cell? [and Discussion] The classical in vitro denaturation-renaturation studies by Anson, Anfinsen, Neurath, Pauling and others clearly suggested that the primary structure of pr... R Jaenicke,AR Clarke,FU Hartl,... - ...
CiteSeerX - Scientific documents that cite the following paper: G protein βγ subunits DE Clapham,EJ Neer - 《Ann Rev Pharmacol》 被引量: 745发表: 1997年 G PROTEIN {beta}{gamma} SUBUNITS. Focuses on the βγ heterotrimer subunits of guanine nucleotide binding (G) proteins. Structure of ...
Osteopontin: a versatile regulator of inflammation and biomineralization Osteopontin is a secreted glycoprotein with a multidomain structure and functions characteristic of a matricellular protein. Osteopontin interacts with cel... CM Giachelli,S Steitz - 《Matrix Biology》 被引量: 860发表: 2000年 ...
The effect of sodium dodecyl sulfate on the enzyme side chains, as expressed by the changes of the bands at 286–294 nm, suggests the involvement of tryptophan residues in these interactions. The CD data also indicate that the ... Y Nakagawa,B Jirgensons - BBA - Protein Structure 被引量...
While the function of podoplanin in different human tissues has been investigated, the biological significance of podoplanin in placental tissue is unclear. The few studies that investigated podoplanin expression in normal and pathological placental tissues, and the role of the protein in placental pathol...
Yin Yang 1 (YY1), a multifunction protein pivotal to numerous cellular processes, is one of the most evolutionarily preserved eukaryotic proteins, suggesting a perfect functional selection. Another unusual feature of YY1 is its amino acid composition, with several low-complexity regions enriched in ...