The human immune system is composed of a distributed network of cells circulating throughout the body, which must dynamically form physical associations and communicate using interactions between their cell-surface proteomes1. Despite their therapeutic potential2, our map of these surface interactions rem...
The following figure is a simple structure diagram of the immune composition. We can generally see that the immunity is divided into immune organs, immune cells and immune molecules. The real immune effects are the immune c...
2. The immune system is a collection of structures, cells, and cell products that can fight external or internal agents harmful to the body. These components and other protective factors of the body will be the topic of this chapter.3. Immunology is the study of the normal functions and ...
The property of CTLA-4 to regulate the immune system has long been exploited in the treatment of RA12. Similarly, an inhibitor for Integrin Subunit Alpha 4, ITGA4 has been trialled in UC and CD (Open Targets database). Our data gives further genetic evidence that an increase in ITGA4 ...
2.2.2. Variable Radius Algorithms The V-detector or Variable Radius Algorithm NSA was initially proposed in Matzinger (2002) shows an evolution in the previous Fig. 1. Diagram evidencing the context of the Self  Nonself theory. The immune...
IIDB uses the MYSQL relational database system to store, retrieve and manage the data. The web interface between the user and IIDB is coded in PERL/CGI. Initially, the database was populated with a set of 1670 genes differentially regulated in response to LPS. We subsequently added a selec...
To understand the complexity in interactions within the HCV induced immune signaling networks, a logic-based diagram is generated based on multiple reported interactions. A simple conceptual framework is presented to explore the key determinants of the immune system and their functions during HCV ...
The innate immune system plays a pivotal role on cardiac fibroblast activation, and sustained inflammation has been linked to the progression of fibrosis (Fig. 3.4). Fig. 3.4 The innate and adaptive immune systems as modulators of fibroblast activity. Various cells of the innate (left) or ...
The present invention relates to the field of Electronic Computing and in particular to a method and respective system for allowing access to data or logic implemented on a device, such as a contactless communication chip device and, in particular, an RFID (Radio Frequency Identification) device,...
These data showed that SUPRA CARs can perform an intercellular AND logic through a stimulus-inducible zipFv secretion system. Fig. 7: The intercellular AND gate using zipFv secretion system. a Diagram of intercellular AND gate logic. CD4+ Sender cells express SYN6 CAR and secrete α-Axl-SYN2...